Ribosomal ubiquitin-like fusion protein: Same same but different?
In most eukaryotes, one ribosomal protein of each subunit is initially translated as an in cis linear fusion with a ubiquitin…
NMD-sensitive transcripts catalogued at unprecedented detail in human cells
Cells harbour a variety of quality control mechanisms to prevent the production and accumulation of harmful proteins. The…
The NCCR RNA & Disease at the Scientifica 2021
On September 4 & 5, 2021, the Scientifica - Zurich Science Days took place, during which ETH Zurich and the University of Zurich showed the public…
Editorial Oliver Mühlemann - The Messenger No. 1
Dear colleagues,
A well functioning research network depends on both, good research and intensive networking. Although that sounds trivial, during…
Ribosomal proteins taking over
In a recently published Science paper, David J. F. Ramrath and Moritz Niemann from the Ban and Schneider groups shed light on the evolutionary shift toward…
Too much Stress and Pressure
Some people with amyotrophic lateral sclerosis or frontotemporal dementia accumulate deposits of the nuclear pro- tein FUS in the cytoplasm. What drives this…
If it’s complex, it’s possibly quadruplex
‘If G-quadruplexes form so readily in vitro, Nature will have found a way of using them in vivo’, said Nobel prize winner Aaron Klug already some decades…
Nuclear RNP assembly and processing machines in human cells
In August 2017, Stefanie Jonas will take up her position as an assistant professor at the Institute of Molecular Biology and Biophysics,…
CLIR sight on protein–RNA interactions
A new method to study protein–RNA interactions at amino acid and nucleotide resolution is proposed by Frédéric H.T. Allain, Ruedi Aebersold et al. It has been…
Protein polymerization preventing pathological aggregation
There are still a lot of unanswered questions when it comes to the pathogenic effects of proteins in connection with ALS and dementia.…