Disclaimer: This page includes all preprints by NCCR member labs.

Preprints

  • J. Farnung, M. Muhar, J. R. Liang, K.A. Tolmachova, R.M. Benoit, J.E. Corn and J.W. Bode (2022) Human ATG3 contains a non-canonical LIR motif crucial for its enzymatic activity in autophagy
    bioRxiv
  • K. M. Thumfart, S. Lazzeri, F. Manuella and I. Mansuy (2022) Long-term effects of early postnatal stress on Sertoli cells functions
    bioRxiv
  • G. Dorn, C. Gmeiner, T. de Vries, E. Dedic, M. Novakovic, F.F. Damberger, C. Maris, E. Finol, C.P. Sarnowski, J. Kolhbrecher, T.J. Welsh, S. Bolisetty, R. Mezzenga, R. Aebersold, A. Leitner, M. Yulikov, G. Jeschke and F.H.-T. Allain (2022) Integrative solution structure of a PTBP1-viral IRES complex reveals strong compaction and ordering with residual conformational flexibility
    bioRxiv
  • M. Katsantoni, E.J. van Nimwegen and M. Zavolan (2022) Improved analysis of (e)CLIP data with RCRUNCH yields a compendium of RNA-binding protein binding sites and motifs
    bioRxiv
  • G. Katsioudi, R. Dreos, E.S. Arpa, S. Gaspari, A. Liechti, M. Sato, C.H. Gabriel, A. Kramer, S.A. Brown and D. Gatfield (2022) A novel Smg6 mouse model reveals regulation of circadian period and daily CRY2 accumulation through the nonsense-mediated mRNA decay pathway
    bioRxiv
  • M. Schmitz, I. Querques, S. Oberli, C. Chanez and M. Jinek (2022) Structural basis for RNA-mediated assembly of type V CRISPR-associated transposons
    bioRxiv
  • P. Simmler, T. Mengis, K. Van-Lehmann, A. Khales, T. Thomas, G. Rätsch, M. Stoffel and G. Schwank (2022) Mutant SF3B1 promotes PDAC malignancy through TGF-B resistance
    bioRxiv
  • A. Taddeo, I. Berenguer Veiga, C. Devisme, R. Boss, P. Plattet, S. Weigang, G. Kochs, V. Thiel, C. Benarafa and G. Zimmer (2022) Optimized intramuscular immunization with VSV-vectored spike protein triggers a superior protective humoral immune response to SARS-CoV-2
    bioRxiv
  • D. Jochmans, C. Liu, K. Donckers, A. Stoycheva, S. Boland, S.K. Stevens, C. De Vita, B. Vanmechelen, P. Maes, B.S. Trüeb, N. Ebert, V. Thiel, S. De Jonghe, L. Vangeel, D. Bardiot, A. Jekle, L.M. Blatt, L. Beigelman, J.A. Symons, P. Raboisson, P. Chaltin, A. Marchand, J. Neyts, J. Deval and K. Vandyck (2022) The substitutions L50F, E166A and L167F in SARS-CoV-2 3CLpro are selected by a protease inhibitor in vitro and confer resistance to nirmatrelvir
    bioRxiv
  • L.M. Muckenfuss, A.C. Migenda Herranz, F.M. Boneberg, M. Clerici and M. Jinek (2022) Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis
    bioRxiv
  • J. Breda, A. Banerjee, J. Pieters, R. Jayachandran and M. Zavolan (2022) A novel approach to single cell analysis to reveal intrinsic differences in immune marker expression in unstimulated macrophages from BALB/c and C57BL/6 mouse strains
    bioRxiv
  • A. Moursy, A. Cléry, S. Gerhardy, K.M. Betz, S. Rao, S. Campagne, I. Beusch, M.M. Duszczyk, M.D. Robinson, V.G. Panse and F. H.-T. Allain (2022) The structure of yeast Npl3 bound to RNA reveals a cooperative sequence-specific recognition and an RNA chaperone role in splicing
    bioRxiv
  • Manuela Pérez-Berlanga, V.I. Wiersma, A. Zbinden, L. De Vos, U. Wagner, C. Foglieni, I. Mallona, K.M. Betz, A. Cléry, J. Weber, Z. Guo, R. Rigort, P. de Rossi, R. Manglunia, E. Tantardini, S. Sahadevan, O. Stach, M. Hruska-Plochan, F.H.-T. Allain, P. Paganetti and M. Polymenidou (2022) TDP-43 oligomerization and RNA binding are codependent but their loss elicits distinct pathologies
    bioRxiv
  • A.D. Holmes, P.P. Chan, Q. Chen, P. Ivanov, L. Drouard, N. Polacek, M.A. Kay and T.M. Lowe (2022) A Standardized Ontology for Naming tRNA-derived RNAs Based on Molecular Origin
    bioRxiv
  • T. Barut, N.J. Halwe, A. Taddeo, J.N. Kelly, J. Schön, N. Ebert, L. Ulrich, C. Devisme, S. Steiner, B.S. Trueeb, B. Hoffmann, I. Berenguer Veiga, N. François G. Leborgne, E. Aquiar Moreira, A. Breithaupt, C. Wylezich, D. Höper, K. Wernike, A. Godel, L. Thomann, V. Flück, H. Stalder, M. Brügger, B.I. Oliveira Esteves, B. Zumkehr, G. Beilleau, A. Kratzel, K. Schmied, S. Ochsenbein, R.M. Lang, M. Wider, C. Machahua, P. Dorn, T.M. Marti, M. Funke-Chambour, A. Rauch, M. Widera, S. Ciesek, R. Dijkman, D. Hoffmann, M.P. Alves, C. Benarafa, M. Beer and V. Thiel (2022) The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype
    bioRxiv
  • J. Beer, S. Crotta, A. Breithaupt, A. Ohnemus, J. Becker, B. Sachs, L. Kern, M. Llorian, N. Ebert, F. Labroussaa, T.T.N. Tran, B.S. Trueeb, J. Jores, V. Thiel, M. Beer, J. Fuchs, G. Kochs, A. Wack, M. Schwemmle and D. Schnepf (2022) Impaired immune response drives age-dependent severity of COVID-19
    bioRxiv
  • S.M. Siegner, A. Clemens, L. Ugalde, L. Garcia-Garcia, J.A. Bueren, P. Rio, M.E. Karasu, and J.E. Corn (2022) Adenine base editing is an efficient approach to restore function in FA patient cells without double-stranded DNA breaks
    bioRxiv
  • C.P. Sarnowski, A. Knörlein, Tebbe de Vries, M, Götze, I. Beusch, R. Aebersold, F.H.-T. Allain, J. Hall and A. Leitner (2022) Sensitive detection and structural characterisation of UV-induced cross-links in protein-RNA complexes using CLIR-MS
    bioRxiv
  • P. Brandys, X. Montagutelli, I. Merenkova, G.T. Barut, V. Thiel, N.J. Schork, B. Trüeb, L. Conquet, A. Deng, A. Antanasijevic, H.-K. Lee, M. Valière, A. Sindhu, G. Singh and J. Herold (2022) A mRNA vaccine encoding for a RBD 60-mer nanoparticle elicits neutralizing antibodies and protective immunity against the SARS-CoV-2 delta variant in transgenic K18-hACE2 mice
    bioRxiv
  • I. Ritsch, E. Lehmann, L. Emmanouilidis, M. Yulikov, F. Allain and G. Jeschke (2022) Phase separation of hnRNP A1 upon specific RNA-binding observed by magnetic resonance
    bioRxiv
  • S. Martinez, R. Weber, T. Woo, A. Malik, M. Geuenich, G. H. Jang, D. Dervovic, K. Al-Zahrani, R. Tsai, N. Fodil, P. Gros, S.S. Sidhu, S. Gallinger, G. Neely, K. Campbell, F. Notta, A. Sendoel and D. Schramek (2022) In vivo CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer
    bioRxiv
  • S. Aeschlimann, A. Kalichava, B. Schimanski, P. Stettler, T. Ochsenreiter and A. Schneider (2022) The mitochondrial genome segregation system of T. brucei: Single p197 molecules connect the basal body with the outer membrane
    bioRxiv
  • M.W.M. Meeuse, S. Nahar, K.n Braun and H. Grosshans (2022) The Grainyhead/LSF transcription factor GRH-1 is rhythmically required for molting
    bioRxiv
  • M. Avar, D. Heinzer, A.M. Thackray, Y. Liu, M. Hruska-Plochan, S. Sellitto, E. Schaper, D.P. Pease, J.-A. Yin, A.K.K. Lakkaraju, M. Emmenegger, M. Losa, A. Chincisan, S. Hornemann, M. Polymenidou, R. Bujdoso and A. Aguzzi (2022) An Arrayed Genome-Wide Perturbation Screen Identifies the Ribonucleoprotein hnRNP K As Rate-Limiting for Prion Propagation
    bioRxiv
  • N. Raad, D. Tandon, S. Hapfelmeier and N. Polacek (2022) The stationary phase-specific sRNA fimR2 is a multifunctional regulator of bacterial motility, biofilm formation and virulence
    bioRxiv
  • B. Hurwitz, N. Guzzi, A. Gola, V.F. Fiore, A. Sendoel, M. Nikolova, D. Barrows, T.S. Carroll, H. Amalia Pasolli and E. Fuchs (2022) The integrated stress response remodels the microtubule organizing center to clear unfolded proteins following proteotoxic stress
    bioRxiv
  • V. Zanki, B. Bozic, M. Mocibob, N. Ban and I. Gruic-Sovulj (2022) A pair of isoleucyl-tRNA synthetases in Bacilli fulfill complementary roles to enhance fitness and provide antibiotic resistance
    bioRxiv
  • M. Flemr, M. Schwaiger, D. Hess, V. Iesmantavicius, A.C. Tuck, F. Mohn and M. Buehler (2022) Mouse Nuclear RNAi-defective 2 Promotes Splicing of Weak 5' Splice Sites
    bioRxiv
  • M. Jambeau, K.D. Meyer, M. Hruska-Plochan, R. Tabet, C.-Z. Lee, A. Ray-Soni, C. Aguilar, K. Savage, N. Mishra, N. Cavegn, P. Borter, C.-C. Lin, K. Jansen-West, J. Jiang, F. Freyermuth, N. Li, P. De Rossi, M. Pérez-Berlanga, X. Jiang, L.M. Daughrity, J. Pereira, S. Narayanan, Y. Gu, S. Dhokai, I. Dalkilic-Liddle, Z. Maniecka, J. Weber, M. Workman, M. McAlonis-Downes, E. Berezovski, Y.-J. Zhang, J. Berry, B.J. Wainger, M.W. Kankel, M. Rushe, C. Hock, R.M. Nitsch, D.W. Cleveland, L. Petrucelli, T. Gendron, F. Montrasio, J. Grimm, M. Polymenidou and Clotilde Lagier-Tourenne (2022) Comprehensive preclinical evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9ORF72 disease
    bioRxiv
  • M. Bak, E. van Nimwegen, R. Schmidt, M. Zavolan and A.J. Gruber (2022) Frequent co-regulation of splicing and polyadenylation by RNA-binding proteins inferred with MAPP
    bioRxiv
  • A. Singh, X.X. Maurer-Alcalá, T. Solberg, S. Gisler, M. Ignarski, E.C. Swart and M. Nowacki (2022) RNA-mediated nucleosome depletion is required for elimination of transposon-derived DNA
    bioRxiv
  • B. Schimanski, S. Aeschlimann, S. Käser, M. Gomez-Fabra Gala, N. Vögtle and A. Schneider (2021) p166 links membrane and intramitochondrial modules of the trypanosomal tripartite attachment complex
    bioRxiv
  • M. Hruska-Plochan, K.M. Hembach, S. Ronchi, V.I. Wiersma, Z. Maniecka, E.-M. Hock, F. Laferriere, S. Sahadevan, V. Hoop, I. Delvendahl, M. Panatta, A. van der Bourg, D. Bohaciakova, K. Frontzek, A. Aguzzi, T. Lashley, M.D. Robinson, T. Karayannis, M. Mueller, A. Hierlemann and M. Polymenidou (2021) Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD
    bioRxiv
  • M. Pacesa, C.-H. Lin, A. Cléry, K. Bargsten, M.J. Irby, F.H.-T. Allain, P. Cameron, P.D. Donohoue and M. Jinek (2021) Structural basis for Cas9 off-target activity
    bioRxiv
  • M. Katsantoni, F. Gypas, C.J. Herrmann, D. Burri, M. Bak, P. Iborra, K. Agarwal, M. Ataman, A. Börsch, M. Zavolan and A. Kanitz (2021) ZARP: An automated workflow for processing of RNA-seq data
    bioRxiv
  • M.S. Kaiser, G. Milan, S. Lin, F. Oliveri, K. Chojnowska, L.A. Tintignac, N. Mittal, C.E. Zimmerli, D.J. Glass, M. Zavolan, D.J. Ham and M.A. Rüegg (2021) Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis
    bioRxiv
  • S. Gómez-Puerta, R. Ferrero, T. Hochstoeger, I. Zubiri, J.A. Chao, T. Aragón and F. Voigt (2021) Live imaging of the co-translational recruitment of XBP1 mRNA to the ER and its processing by diffuse, non-polarized IRE1alpha
    bioRxiv
  • R. Esposito, A. Lanzos, T. Polidori, H. Guillen-Ramirez, B. Merlin, L. Mela, E.o Zoni, I. Buechi, L. Hovhannisyan, F. McCluggage, M. Medo, G. Basile, D.F. Meise, S. Ramnarayanan, S. Zwyssig, C. Wenger, K. Schwarz, A. Vancura, N. Bosch-Guiteras, M. Kruithof-de Julio, Y. Zimmer, M. Medova, D. Stroka, A. Fox and R. Johnson (2021) Tumour mutations in long noncoding RNAs that enhance cell fitness
    bioRxiv
  • M. Gultom, A. Kratzel, J. Portmann, H. Stalder, A. Chanfon Baetzner, H. Gantenbein, C. Gurtner, N. Ebert, H. Posthaus, P. Zanolari, S. Pfaender, V. Thiel and R. Dijkman (2021) Establishment of well-differentiated camelid airway cultures to study Middle East respiratory syndrome coronavirus
    bioRxiv
  • R. Arora, M. Bodak, L. Penouty, C. Hackmann and C. Ciaudo (2021) Sequestration of LINE-1 in novel cytosolic bodies by MOV10 restricts retrotransposition
    bioRxiv
  • R. Esposito, T. Polidori, D. Meise, C. Pulido, P. Chouvardas, S. Forster, P. Schaerer, A. Kobel, J. Schlatter, M. Roemmele, E. Westemeier, L. Zhu, A. Lanzos, H. Guillen-Ramirez, G. Basile, I. Carrozzo, A. Vancura, S. Ullrich, P. Medina, A. Andreades, D. Harvey, P. Ma, S. Haefliger, X. Wang, I. Martinez, A. Ochsenbein, C. Riether and R. Johnson (2021) Multi-hallmark long noncoding RNA maps reveal non-small cell lung cancer vulnerabilities
    bioRxiv
  • R. Nurtdinov, M. Sanz, A. Abad, A. Esteban, S. Ullrich, C. Arnan, R. Johnson, S. Perez-Lluch and R. Guigo (2021) Alu-mediated weak CEBPA binding and slow B cell transdifferentiation in human
    bioRxiv
  • D. Niemeyer, S. Schroeder, K. Friedmann, F. Weege, J. Trimpert, A. Richter, S. Stenzel, J. Jansen, J. Emanuel, J. Kazmierski, F. Pott, L.M. Jeworowski, R. Olmer, M.-C. Jaboreck, B. Tenner, J. Papies, J. Heinze, F. Walper, M.L. Schmidt, N. Heinemann, E. Moencke-Buchner, T. Veith, M. Baumgardt, K. Hoffmann, M. Widera, T.T.N. Thao, A. Balazs, J. Schulze, C. Mache, M. Morkel, S. Ciesek, L.G. Hanitsch, M. Mall, A.C. Hocke, V. Thiel, K. Osterrieder, T. Wolff, U. Martin, V.M. Corman, M.A. Mueller, C. Goffinet and C. Drosten (2021) Post-entry, spike-dependent replication advantage of B.1.1.7 and B.1.617.2 over B.1 SARS-CoV-2 in an ACE2-deficient human lung cell line
    bioRxiv
  • M. Mueller, M. Schaefer, T. Faeh, D. Spies, R. Peña-Hernández, R. Santoro and C. Ciaudo (2021) ARGONAUTE proteins regulate a specific network of genes through KLF4 in mouse embryonic stem cells
    bioRxiv
  • C.E. Dewar, S. Oeljeklaus, B. Warscheid and A. Schneider (2021) Characterisation of a highly diverged mitochondrial ATP synthase peripheral stalk subunit b in Trypanosoma brucei
    bioRxiv
  • M. Pacesa and M. Jinek (2021) Mechanism of R-loop formation and conformational activation of Cas9
    bioRxiv
  • C.E. Dewar, S. Oeljeklaus, J. Mani, W.W.D. Mühlhäuser, B. Warscheid and A. Schneider (2021) Mistargeting of hydrophobic mitochondrial proteins activates a nucleus-mediated posttranscriptional quality control pathway in trypanosomes
    bioRxiv
  • A.B. Eberle, K. Schranz, S. Nasif, L. Grollmus and Oliver Mühlemann (2021) Dissecting the import and export pathways of the human RNA helicase UPF1
    bioRxiv
  • A.J. Hume, B. Heiden, J. Olejnik, E.L. Suder, S. Ross, W.A. Scoon, E. Bullitt, M. Ericsson, M.R. White, J. Turcinovic, T.T.N. Thao, R. M. Hekman, J.E. Kaserman, J. Huang, K. Alysandratos, G.E. Toth, F. Jakab, D.N. Kotton, A.A. Wilson, A. Emili, V. Thiel, J.H. Connor, G. Kemenesi, D. Cifuentes and E. Mühlberger (2021) Recombinant Lloviu virus as a model to study inaccessible zoonotic viruses
    bioRxiv
  • A. Brümmer, R. Dreos, A.C. Marques and S. Bergmann (2021)Analysis of eukaryotic lincRNA sequences reveals signatures of repressed translation in species under strong selection
    bioRxiv
  • M. Roganowicz, D. Baer and R. Santoro (2021) BAZ2A-RNA mediated association with TOP2A and KDM1A represses gene expression in prostate cancer
    bioRxiv
  • A. Kroupova, F. Ackle, F.M. Boneberg, A. Chui, S. Weitzer, M. Faini, A. Leitner, R. Aebersold, J. Martinez and M. Jinek (2021) Molecular architecture of the human tRNA ligase complex
    bioRxiv
  • I. Querques, M. Schmitz, S. Oberli, C. Chanez and M. Jinek (2021) Molecular mechanism of target site selection and remodeling by type V CRISPR-associated transposons
    bioRxiv
  • Y.P. Hauser, M.W.M. Meeuse, D. Gaidatzis and H. Grosshans (2021) The BLMP-1 transcription factor promotes oscillatory gene expression to achieve timely molting
    bioRxiv
  • R. Weber, U. Ghoshdastider, D. Spies, C. Dure, F. Valdivia-Francia, M. Forny, M. Ormiston, P.F. Renz, D. Taborsky, M. Yigit, H. Yamahachi and A. Sendoel (2021) Monitoring the 5`UTR landscape reveals 5`terminal oligopyrimidine (TOP) motif switches to drive translational efficiencies
    bioRxiv
  • M. Mueller, T. Faeh, M. Schaefer, J. Luitz, P. Stalder, R. Arora, R.P. Ngondo and C. Ciaudo (2021) AGO1 regulates major satellite transcripts and H3K9me3 distribution at pericentromeric regions in mESCs
    bioRxiv
  • D. Burri and M. Zavolan (2021) Shortening of 3' UTRs in most cell types composing tumor tissues implicates alternative polyadenylation in protein metabolism
    bioRxiv
  • S. Ullrich, C. Arnan, C. Pulido-Quetglass, R.N. Nurtdinov, A. Esteban, J. Blanco, E. Aparicio-Prat, R. Johnson, S. Perez-Lluch and R. Guigo (2021) Paired guide RNA CRISPR-Cas9 screening for protein-coding genes and lncRNAs involved in transdifferentiation of human B-cells to macrophages
    bioRxiv
  • T.J. Böddeker, K.A. Rosowski, D. Berchtold, L. Emmanouilidis, Y. Han, F.H.-T. Allain, R.W. Style, L. Pelkmans and E.R. Dufresne (2021) Non-specific adhesive forces between filaments and membraneless organelles
    bioRxiv
  • J. van den Heuvel, C. Ashiono, L. Gillet, K. Doerner, E. Wyler, I. Zemp and U. Kutay (2021) Processing of the Ribosomal Ubiquitin-Like Fusion Protein FUBI-eS30/FAU is Required for 40S Maturation and Depends on USP36
    bioRxiv
  • K. Tabata, V. Prasad, D. Paul, J.-Y. Lee, M.-T. Pham, W.-I. Twu, C.J. Neufeldt, M. Cortese, B. Cerikan, C.S. Tran, C. Luechtenborg, P. Vkovski, K. Hoermann, A. Mueller, C. Zitzmann, U. Haselmann, J. Beneke, L. Kaderali, H. Erfle, V. Thiel, V. Lohmann, G. Superti-Furga, B. Bruegger and R. Bartenschlager (2021) Convergent use of phosphatidic acid for Hepatitis C virus and SARS-CoV-2 replication organelle formation
    bioRxiv
  • L. Ulrich, N.J. Halwe, A. Taddeo, N. Ebert, J. Schön, C. Devisme, B.S. Trüeb, B. Hoffmann, M. Wider, M. Bekliz, M. Essaidi-Laziosi, M.L. Schmidt, D. Niemeyer, V.M. Corman, A. Kraft, A. Godel, L. Laloli, J.N. Kelly, A. Breithaupt, C. Wylezich, I.M. Berenguer Veiga, M. Gultom, K. Adea, B. Meyer, C. Eberhardt, L. Thomann, M. Gsell-Albert, F. Labroussaa, J. Jores, A. Summerfield, C. Drosten, I.A. Eckerle, R. Dijkman, D. Hoffmann, V. Thiel, M. Beer and C. Benarafa (2021) Enhanced fitness of SARS-CoV-2 variant of concern B.1.1.7, but not B.1.351, in animal models
    bioRxiv
  • A. Iyer, M. Niemann, L. Farine, M. Serricchio, A. Schneider and P. Bütikofer (2021) The endoplasmic reticulum membrane protein complex localizes to the mitochondrial - endoplasmic reticulum interface and its subunits modulate phospholipid biosynthesis in Trypanosoma brucei
    bioRxiv
  • P. Dave, E. Griesbach, G. Roth, D. Mateju and J. Chao (2021) Single-molecule imaging reveals the coupling of translation and mRNA decay
    bioRxiv
  • D.J. Ham, A. Boersch, K. Chojnowska, S. Lin, A.B. Leuchtmann, A.S. Ham, M. Thuerkauf, J. Delezie, R. Furrer, D. Burri, M. Sinnreich, C. Handschin, L.A. Tintignac, M. Zavolan, N. Mittal, M.A. Ruegg (2021) Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle
    bioRxiv
  • L.-A. Gurzeler, J. Ziegelmuller, O. Mühlemann and E.D. Karousis (2021) Production of human translation-competent lysates using dual centrifugation
    bioRxiv
  • R. Dijkman, M. Selvaraj, H.H. Gad, S. More, R. Hartmann, S. Perlman, V. Thiel and R. Channappanavar (2021) Effective interferon (IFN)-lambda treatment regimen to control lethal MERS-CoV infection in mice
    bioRxiv
  • K. Tabata, V. Prasad, D. Paul, J.-Y. Lee, M.-T. Pham, W.-I. Twu, C.J. Neufeldt, M. Cortese, B. Cerikan, C.S. Tran, C. Luechtenborg, P. Vkovski, K. Hoermann, A. Mueller, C. Zitzmann, U. Haselmann, J. Beneke, L. Kaderali, H. Erfle, V. Thiel, V. Lohmann, G. Superti-Furga, B. Bruegger and R. Bartenschlager (2021) Convergent use of phosphatidic acid for Hepatitis C virus and SARS-CoV-2 replication organelle formation
    bioRxiv
  • M. Emmenegger, E. De Cecco, M. Hruska-Plochan, T. Eninger, M.M. Schneider, M. Barth, E. Tantardini, P. de Rossi, M. Bacioglu, R.G. Langston, A. Kaganovich, N. Bengoa-Vergniory, A. Gonzalez-Guerra, M. Avar, D. Heinzer, R. Reimann, L.M. Häsler, T.W. Herling, N.S. Matharu, N. Landeck, K. Luk, R. Melki, P.J. Kahle, S. Hornemann, T.P.J. Knowles, M.R. Cookson, M. Polymenidou, M. Jucker and A. Aguzzi (2021) LAG3 is not expressed in human and murine neurons and does not modulate a-synucleinopathies
    bioRxiv
  • E.D. Karousis, F. Gypas, M. Zavolan and O. Mühlemann (2021)Nanopore sequencing reveals endogenous NMD-targeted isoforms in human cells
    bioRxiv
  • G. Holzer, P. De Magistris, C. Gramminger, R. Sachdev, A. Magalska, A. Schooley, A. Scheufen, B. Lennartz, M. Tatarek-Nossol, H. Lue, M.I. Linder, U. Kutay, C. Preisinger, D. Moreno-Andres and W. Antonin (2021) The nucleoporin Nup50 activates the Ran guanyl-nucleotide exchange factor RCC1 to promote mitotic NPC assembly
    bioRxiv
  • J.A. Ruland, A.M. Krueger, K.E. Doerner, R. Bhatia, S. Wirths, D. Poetes, U. Kutay, J.P. Siebrasse and U. Kubitscheck (2021) Nuclear export of the pre-60S ribosomal subunit through single nuclear pores observed in real time
    bioRxiv
  • M. Calon, A.A. Malar, S. Pfister, V. Rimal, M.E. Weber, T. Wiegand, J. Zehnder, M. Chavez, R. Deb, R. Cadalbert, A. Dapp, M.-L. Fogeron, A. Hunkeler, L. Lecoq, A. Torosyan, D. Zyla, R. Glockshuber, S. Jonas, M. Nassal, M. Ernst, A. Bockmann and B.H. Meier (2021) Biomolecular solid-state NMR spectroscopy at highest field: the gain in resolution at 1200 MHz
    bioRxiv
  • T. Lenarcic, M. Jaskolowski, M. Leibundgut, A. Scaiola, T. Schoenhut, M. Saurer, R. Lee, O. Rackham, A. Filipovska and N. Ban (2021) Stepwise maturation of the peptidyl transferase region of human mitoribosomes
    bioRxiv
  • B.D. Tobwin and H. Grosshans (2021) A folder mechanism ensures size uniformity among C. elegans individuals by coupling growth and development
    bioRxiv
  • K.M. Hannan, P. Soo, M.S. Wong, J.K. Lee, N. Hein, M. Evers, K.D. Wysoke, T.D. Williams, C. Montellese, L. Smith, S.J. Al-Obaidi, L. Núñez-Villacís, P.a Poh, M. Pavy, J.-S. He, K.M. Parsons, J. Diesch, G. Burgio, R. Ferreira, Z.-P. Feng, C.M. Gould, P.B. Madhamshettiwar, J. Flygare, T.J. Gonda, K.J. Simpson, U. Kutay, R.B. Pearson, C. Engel, N. Watkins, R.D. Hannan and A.J. George (2021) Nuclear stabilisation of p53 requires a functional nucleolar surveillance pathway
    bioRxiv
  • E. Kummer, K.N. Schubert, T. Schönhut, A. Scaiola and N. Ban (2021) Release, rescue and recycling: termination of translation in mammalian mitochondria
    bioRxiv
  • F. Gruhl, P. Janich, H. Kaessmann and D. Gatfield (2021) Circular RNA repertoires are associated with evolutionarily young transposable elements
    bioRxiv
  • A. Kratzel, J.N. Kelly, Y. Brueggemann, J. Portmann, P. V'kovski, D. Todt, N. Ebert, E. Steinmann, R. Dijkman, G. Zimmer, S. Pfaender and V. Thiel (2021) A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets
    bioRxiv
  • M. Krepl, F. Damberger, C. von Schroetter, D. Theler, P. Pokorna, F. Allain and J. Sponer (2021) Recognition of N6-methyladenosine by the YTHDC1 YTH domain studied by molecular dynamics and NMR spectroscopy: The role of hydration
    bioRxiv
  • S. Tetter, N. Terasaka, A. Steinauer, R.J. Bingham, S. Clark, A.P. Scott, N. Patel, M. Leibundgut, E. Wroblewski, N. Ban, P.G. Stockley, R. Twarock and D. Hilvert (2020) Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein
    bioRxiv
  • O. Garcia-Nicolas, P. V'kovski, F. Zettl, G. Zimmer, V. Thiel and A. Summerfield (2020) No evidence for human monocyte-derived macrophage infection and antibody-mediated enhancement of SARS-CoV-2 infection
    bioRxiv
  • B.Th. Eichenberger, Y.X. Zhan, M. Rempfler, L. Girogetti and J. Chao (2020) deepBlink: Threshold-independent detection and localization of diffraction-limited spots
    bioRxiv
  • R.K. Gudipati, K. Braun, F. Gypas, D. Hess, J. Schreier, S.H. Carl, R. Ketting and H. Grosshans (2020) Protease-mediated processing of Argonaute proteins controls small RNA association
    bioRxiv
  • B. Krasniqi, A. Stevaert, B. Van Loy, T. Nguyen, J. Thomas, J. Vandeput, D. Jochmans, V. Thiel, R. Dijkman, W. Dehaen, A. Voet and L. Naesens (2020) Betulonic acid derivatives inhibiting coronavirus replication in cell culture via the nsp15 endoribonuclease
    bioRxiv
  • N. Luithle, J. uit de Bos, R. Hovius, D. Maslennikova, R. Lewis, R. Ungricht, B. Fierz, U. Kutay (2020) Torsin ATPases influence chromatin interaction of the Torsin regulator LAP1
    bioRxiv
  • B. Borsari, A. Abad, C. Coimbra Klein, R. Nurtdinov, A. Esteban, E. Palumbo, M. Ruiz-Romero, M. Sanz, B.R. Correa, R. Johnson, S. Pérez-Lluch, R. Guigó (2020) Dynamics of gene expression and chromatin marking during cell state transition
    bioRxiv
  • M. Gultom, M. Licheri, L. Laloli, M. Wider, M. Straessle, S. Steiner, A. Kratzel, T.T.N. Thao, H. Stalder, J. Portmann, M. Holwerda, P. V'kovski, N. Ebert, N. Stokar-Regenscheit, C. Gurtner, P. Zanolari, H. Posthaus, S. Schuller, A. Moreira-Soto, A. Vicente-Santos, E. Corrales-Aguilar, N. Ruggli, G. Tekes, V. von Messling, B. Sawatsky, V. Thiel, R. Dijkman (2020) Susceptibility of well-differentiated airway epithelial cell cultures from domestic and wildlife animals to SARS-CoV-2
    bioRxiv
  • P. Simmler, C. Cortijo, L.M. Koch, P. Galliker, S. Angori, H.A. Bolck, C. Mueller, A. Vukolic, P. Mirtschink, Y. Christinat, N.R. Davidson, K.-V. Lehmann, G. Pellegrini, C. Pauli, D. Lenggenhager, I. Guccini, T. Ringel, C. Hirt, G. Raetsch, H. Moch, M. Stoffel, G. Schwank (2020) SF3B1 promotes tumor malignancy through splicing-independent co-activation of HIF1alpha
    bioRxiv
  • B. Zhou, T.T.N. Thao, D. Hoffmann, A. Taddeo, N. Ebert, F. Labroussaa, A. Pohlmann, J. King, J. Portmann, N. J. Halwe, L. Ulrich, B.S. Trueb, J.N. Kelly, X. Fan, B. Hoffmann, S. Steiner, L. Wang, L. Thomann, X. Lin, H. Stalder, B. Pozzi, S. de Brot, N. Jiang, D. Cui, J. Hossain, M. Wilson, M.W. Keller, T.J. Stark, J.R. Barnes, R. Dijkman, J. Jores, C. Benarafa, D.E. Wentworth, V. Thiel and M. Beer (2020) SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility
    bioRxiv
  • P.R. Bhatt, A. Scaiola, G. Loughran, M. Leibundgut, A. Kratzel, A. McMillan, K.M. O’ Connor, J.W. Bode, V. Thiel, J.F. Atkins, N. Ban (2020) Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome
    bioRxiv
  • L. Contu, G. Balistreri, M. Domanski, A. Uldry, O. Mühlemann (2020) Characterisation of the Semliki Forest Virus-host cell interactome reveals the viral capsid protein as an inhibitor of nonsense-mediated mRNA decay
    bioRxiv
  • M. Linder, D. Liko, V. Kancherla, S. Piscuoglio, M.N. Hall (2020) Colitis is associated with loss of LHPP and up-regulation of histidine phosphorylation in intestinal epithelial cells
    bioRxiv
  • N. Bakhtina, M. Muller, H. Wischnewski, R. Arora, C. Ciaudo (2020) 3D synthetic microscaffolds promote homogenous expression of NANOG in mouse embryonic stem cells
    bioRxiv
  • L. Plassart, R. Shayan, C. Montellese, D. Rinaldi, N. Larburu, C. Pichereaux, S. Lebaron, M. O’Donohue, U. Kutay, J. Marcoux, P. Gleizes, C. Plisson-Chastang (2020) The final step of 40S ribosomal subunit maturation is controlled by a dual key lock
    bioRxiv
  • A. Vancura, A. Lanzós, N. Bosch, M. Torres, S. Häfliger and R. Johnson (2020) Semi-automated annotation of known and novel cancer long noncoding RNAs with the Cancer LncRNA Census 2 (CLC2)
    bioRxiv
  • N. Bosch, M. Medová, R. Esposito, C. Pulido-Quetglas, Y. Zimmer and R. Johnson (2020) Enhancing CRISPR deletion via pharmacological delay of DNA-PK
    bioRxiv
  • P. Sharma, B.S. Nilges, J. Wu and S.A. Leidel (2019) The translation inhibitor cycloheximide affects ribosome profiling data in a species-specific manner
    bioRxiv
  • S. Reber, H. Lindsay, A. Devoy, D. Jutzi, J. Mechtersheimer, M. Domanski, O. Mühlemann, S.M.L. Barabino and M.-D. Ruepp (2019) The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation
    bioRxiv
  • S.C. Lenzken, B.R. Levone, G. Filosa, M. Antonaci, F. Conte, C. Kizilirmak, S. Reber, A. Loffreda, F. Biella, A.E. Ronchi, O. Mühlemann, A. Bachi, M.-D. Ruepp and S.M.L. Barabino (2019) FUS-dependent phase separation initiates double-strand break repair
    bioRxiv
  • I. Ferro, J. Gavini, L. Bracher, M. Landolfo, D. Candinas, D. Stroka and N. Polacek (2020) The human vault RNA enhances tumorigenesis and chemoresistance through the lysosome
    bioRxiv
  • G. Yang, C. Heisenberger, I.C. Kos-Braun, N. Polacek, J. Grillari, M. Schosserer and M. Koš1 (2020) Cellular senescence and quiescence are associated with altered ribosomal RNA methylation and processing
    bioRxiv
  • A. Stukalov, V. Girault, V. Grass, V. Bergant, O. Karayel, C. Urban, D.A. Haas, Y. Huang, L. Oubraham, A. Wang, S.M. Hamad, A. Piras, M. Tanzer, F. M. Hansen, T. Enghleitner, M. Reinecke, T.M. Lavacca, R. Ehmann, R. Wölfel, J. Jores, B. Kuster, U. Protzer, R. Rad, J. Ziebuhr, V. Thiel, P. Scaturro, M. Mann and Andreas Pichlmair (2020) Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV
    bioRxiv
  • M. Holwerda, P. V’kovski, M. Wider, V. Thiel and R. Dijkman (2020) Identification of five antiviral compounds from the Pandemic Response Box targeting SARS-CoV-2
    bioRxiv
  • P. V’kovski, M. Gultom, S. Steiner, J. Kelly, J. Russeil, B. Mangeat, E. Cora, J. Pezoldt, M. Holwerda, A. Kratzel, L. Laloli, M. Wider, J. Portmann, T. Tran, N. Ebert, H. Stalder, R. Hartmann, V. Gardeux, D. Alpern, B. Deplancke, V. Thiel and R. Dijkman (2020) Disparate temperature-dependent virus – host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium
    bioRxiv
  • J.N. Kelly, L. Laloli, P. V’kovski, M. Holwerda, J. Portmann, V. Thiel and R. Dijkman (2020) Comprehensive single cell analysis of pandemic influenza A virus infection in the human airways uncovers cell-type specific host transcriptional signatures relevant for disease progression and pathogenesis
    bioRxiv
  • N.S. Ravi, B. Wienert, S.K. Wyman, J. Vu, A.A. Pai, P. Balasubramanian, Y. Nakamura, R. Kurita, S. Marepally, S. Thangavel, S.R. Velayudhan, A. Srivastava, M.A. DeWitt, J.E. Corn and K.M. Mohankumar (2020) Identification of novel HPFH-like mutations by CRISPR base editing that elevates the expression of fetal hemoglobin
    bioRxiv
  • R. Baik, S.K. Wyman, S. K. and J.E. Corn (2019) Genome editing to model and reverse a prevalent mutation associated with myeloproliferative neoplasms
    bioRxiv
  • M.M. Duszczyk, H. Wischnewski, T. Kazeeva, F.E. Loughlin, C. von Schroetter, U. Pradère, J. Hall, C. Ciaudo and F.H.-T. Allain (2019) The solution structure of Dead End bound to AU-rich RNA reveals an unprecedented mode of tandem RRM-RNA recognition required for mRNA regulation
    bioRxiv
  • T.C.S. Mak, Y. von Ohlen, Y. Fang Wang, E. Kane, K. Jurgaityte, P. Ervilha, P. Chabosseau, W. Distaso, V. Salem, A. Tomas, M. Stoffel, P. Marchetti, A.M.J. Shapiro, G.A. Rutter and M. Latreille (2019) B-cell dedifferentiation is associated with epithelial-mesenchymal transition triggered by miR-7-mediated repression of mSwi/Snf complex
    bioRxiv
  • J. Scekic-Zahirovic, I. Sanjuan-Ruiz, V. Kan, S. Megat, P. De Rossi, S. Dieterlé, R. Cassel, P. Kessler, D. Wiesner, L. Tzeplaeff, V. Demais, H.-P. Muller, G. Picchiarelli, N. Mishra, S. Dirrig-Grosch, J. Kassubek, V. Rasche, A. Ludolph, A.-L. Boutillier, M. Polymenidou, C. Lagier-Tourenne, S. Liebscher and L. Dupuis (2020) Cytoplasmic accumulation of FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and defects in inhibitory synapses
    bioRxiv
  • S. Sahadevan, K.M. Hembach, E. Tantardini, M. Pérez-Berlanga, M. Hruska-Plochan, J. Weber, P. Schwarz, L. Dupuis, M.D. Robinson, P. De Rossi and M. Polymenidou (2020) Synaptic accumulation of FUS triggers age-dependent misregulation of inhibitory synapses in ALS-FUS mice
    bioRxiv
  • D. Mateju, B. Eichenberger, J. Eglinger, G. Roth and J.A. Chao (2020) Single-molecule imaging reveals translation of mRNAs localized to stress granules
    bioRxiv
  • A. Scaiola, F. Mangia, S. Imseng, D. Boehringer, K. Berneiser, M. Shimobayashi, E. Stuttfeld, M.N. Hall, N. Ban and T. Maier (2020) The 3.2Å resolution structure of human mTORC2
    bioRxiv
  • M. Shimobayashi, S. Shetty, I.C. Frei, B.K. Wölnerhanssen, D. Weissenberger, N. Dietz, A. Thomas, D. Ritz, A.C. Meyer-Gerspach, T. Maier, N. Hay, R. Peterli, N. Rohner and M.N. Hall (2020) Diet-induced loss of adipose Hexokinase 2 triggers hyperglycemia
    bioRxiv
  • D. Benjamin, M. Colombi, C. Moroni and M.N. Hall (2019) mTOR dependent transformed human cells have a distinct set of essential genes from bcr-abl transformed cells
    bioRxiv
  • S. Ghosh, A. Börsch and M. Zavolan (2020) The transcriptional landscape of a hepatoma cell line grown on scaffolds of extracellular matrix proteins
    bioRxiv
  • J. Breda, M. Zavolan and E. van Nimwegen (2029) Bayesian inference of the gene expression states of single cells from scRNA-seq data
    bioRxiv
  • C.-Y. Gabriela Lin, A.C. Näger, T. Lunardi, A. Vancevska, G. Lossaint and J. Lingner (2020) The Human Telomeric Proteome During Telomere Replication
    bioRxiv
  • A.-S. Briod, G. Glousker and J. Lingner (2020) RADX Sustains POT1 Function at Telomeres to Counteract RAD51 Binding, which Triggers Telomere Fragility
    bioRxiv
  • J.Y. Tan, B. Abdulkarim and A.C. Marques (2020) Noncanonical targeting contributes significantly to miRNA-mediated regulation
    bioRxiv
  • M. Hersch, A. Biasini, A.C. Marques and S. Bergmann (2020) Estimating RNA dynamics using one time point for one sample in a single-pulse metabolic experiment
    bioRxiv
  • A. Brümmer, R. Dreos, A.C. Marques and S. Bergmann (2020) LincRNA sequences are biased to counteract their translation
    bioRxiv
  • A. Biasini, S. de Pretis, J.Y. Tan, B. Abdulkarim, H. Wischnewski, R. Dreos, M. Pelizzola, C. Ciaudo and A.C. Marques (2020) Translation is required for miRNA-dependent decay of endogenous transcripts
    bioRxiv
  • D. Dalcher, J.Y., C. Bersaglieri, R. Peña-Hernández, E. Vollenweider, S. Zeyen, Ma.W. Schmid, V. Bianchi, S. Butz, R. Kuzyakiv, T. Baubec, A.C. Marques and R. Santoro (2019) TIP5 safeguards genome architecture of ground-state pluripotent stem cells
    bioRxiv
  • R. Peña-Hernández, R. Aprigliano, S. Frommel, K. Pietrzak, S. Steiger, M. Roganowicz, J. Bizzarro and R. Santoro (2020) BAZ2A association with H3K14ac is required for the dedifferentiation of prostate cancer cells into a cancer stem-like state
    bioRxiv