News Listing

Diabetes and fatty liver disease can be caused by hyperglycemia which in turn can be caused by obesity. However, the linking mechanism is unkown. The lab of Michael Hall and collaborators could now show that a high-fat diet in mice leads to the loss of Hexokinase 2 in adipose tissue. This loss…

The Pillai lab found that in vivo mouse MIWI cleaves targets containing mismatches at certain positions while in vitro such targets are not sliced. In addition they discovered that not all PIWI slicing targets become mature piRNAs. Their findings were published in the article "In vivo PIWI slicing…

When nutrients are limited, cells keep a pool of dormant ribosomes which get activated, when nutrients become available again. The lab of Michael Hall now found that in yeast the protein Stm1 controls the formation of dormant ribosomes. When nutrients become availalbe again TORC1 phosporylates Stm1…

The ciliate Paramecium tetraurelia's genome enodes many PIWI-clade proteins, of many of which the function is unkown. One of them is called Ptiwi08, which is expressed only shortly during development. The Nowacki lab found out that Ptiwi08 degrades untranslated mRNAs at this developmental transition…

Jonathan Hall wrote a perspective article which in his view the future directions for medicinal chemistry in the field of Oligonucleotide Therapeutics are. The article entitled " Future directions for medicinal chemistry in the field of oligonucleotide therapeutics " has been published in RNA.

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The Kutay lab wrote a review on the complex process of ribosomal biogenesis and the plethora of factors involved in it, comparting the factors involved in yeast and humans. Their article "Ribosome biogenesis factors-from names to functions" has been published online in the EMBO Journal.

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At the end of January and beginning of February, three NCCR RNA & Disease related in-person events took place in Bern and Kandersteg.

On Thursday, January 26, 2023, the first Swiss RNA Therapeutics Summit took place in Bern jointly organized by the NCCR RNA & Disease and the Swiss Biotech…

FMI News Article
In the cell, messenger RNAs — or mRNAs — are translated into proteins and eventually degraded, but the relationship between translation and mRNA decay remains cloudy. FMI researchers developed an innovative tool to control and visualize mRNA translation and decay, one molecule at…

Welcome to Pei-Hsuan (Xuan) Wu as a new associate member of the NCCR RNA & Disease!

FMI News Article
Shrimps, flies and other animals shed their outer body covering at specific times of the year or at specific points in their life cycles through a process called molting. Working in worms, FMI researchers identified the mechanisms underlying a molecular ‘molting clock’ — as well as…