Inhibiting ribosome biogenesis is a promising strategy for treating cancers. Despite the many factors involved that could represent potential drug targets only few inhibitors have been identified to date. To help this aim, the Kutay and Horvath labs…
Non-tuberculous mycobacteria are an emerging health threat and are difficult to treat due to their high resistance to antibiotics. Mycobacterium abcessus causes particularly difficult to treat infections with an estimated mortality of 50% over 15…
This paper in “Nature Chemistry” by the Allain Group (IBC) presents an NMR method to characterize condensates formed by disease-associated CAG-repeat RNA. The method uses water-detection, revealing that such condensates are semi-solid and contain…
How does metabolism intersect with fundamental principles in translation regulation? And how does introducing a pro-differentiation proteome lead to cures in highly malignant mouse models via a "Reverse Yamanaka-Effect"? Read more about this recent…
ETH News Article / Artikel Thanks to CRISPR/Cas technology, researchers can precisely edit genetic material to treat hereditary diseases. To achieve this, they need to identify undesirable cuts in the genome at an early juncture. Pioneer Fellow Lilly…
Unlike other organisms, trypanosomes have only one translocases of the inner membrane (TIM) complex to import proteins across the inner mitochondrial membrane. The Schneider lab and collaborators now investigated one of its subunits, TbTim20, which…
Up-frameshift 1 (UPF1) is an essential protein and key to Nonsense Mediated Decay (NMD). UPF1 is an ATP-dependent RNA helicase and was shown to shuttle between the cytoplasm and the nucleus, with most of the protein residing in the cytoplasm. The…
ETH News Article / Artikel Do cells contain a mechanism that decides on their fates? Researchers at ETH Zurich have demonstrated in a new study that large clusters of molecules determine a cell’s future.
On September 6, 2025, we had the pleasure of presenting our booth, “RNA – Master of Versatility”, at the ‘Nacht der Forschung’ (Science Night) at the University of Bern. It was a fantastic evening full of curiosity, engaging questions, and lively…
