University of Basel News Article / News Artikel Universität Basel
Researchers have developed an approach to “deleting” a blood system affected by leukemia while simultaneously building up a new, healthy system with donor blood stem cells. Writing in…

The Gatfield and Galy labs investigated the rhytmic regulation of iron homeostasis through the control of iron responsive element (IRE) containing mRNAs. These were thought to be regulated in the liver mainly by iron regulatory protein 2 (IRP2) and…

A new method paper published by the Ban group (IMBB) in “Cell Reports Methods” describes the production and use of an improved Human In-vitro Translation System (HITS), that is capable of highly efficient and regulated ribosomal protein synthesis in…

On May 1, 2014, the NCCR RNA & Disease was established and started its operations.

Mitochondria import nearly all of their proteins using inner membrane protein translocases (TIMs). Opposite to other eukaryotes, trypanosomes only have one type of TIM. The Schneider  and Warscheid labs could now identify a new essential component of…

Congratulations to Nenad Ban on being elected as a Member of the American Academy of Arts & Sciences which honors excellence and leadership! The academy was founded in 1780, four years after the founding of the USA, and has the motto “They flourish…

The Allain lab (IBC) in a "Molecular Biology of the Cell" paper reported that the phase separation of the SARS-CoV-2 N protein strongly depends on the chosen buffer and pH. For example, the protonation of a single histidine side chain makes the…

Pro- and eukaryotic ribosomes contain very similar active centers, but eukaryotic ribosomes have a higher translational accuracy than their prokaryotic counterparts. Also, they have acquired expansions in their proteins and rRNA which could underlie…

The Allain and Campagne labs previously elucidated the binding mode of the SMN-C5 splicing modifier molecule to its target RNA, a 5'-splice site in the SMN2 mRNA, and called its mode of action 5'-splice site bulge repair. They followed up this study…

Feline coronavirus causes feline infectious peritonitis a lethal disease killing cats worlwide. The Thiel and Tekes labs created a replicon system for drug screening which is itself non-infectious, and tested several compounds for their antiviral…