Last week, the 5th NCCR RNA & Disease Summer School ‘RNA: Heterogeneity in Chemistry, Space, and Time’ took place in Saas-Fee, Switzerland, from 26 - 30 August 2024.
The Zavolan lab in collaboration with the Spang lab and the NCCR Cryo-EM platform, investigated the expression, structure within the ribosome and function of the ribosomal protein paralog 39L (RPL39L). They could detect RPL39L expression in other…
Disturbed pseudouridine metabolism is linked to human genetic diseases. Pseudouridine synthase 3 (PUS3) is responsible for the formation of pseudouridine at position 38/39 in tRNAs. The Leidel and Glatt labs determined four Cryo-EM structures of the…
Right on time for August 1, the Swiss National Holiday and the International RNA Day we are happy to release our next public outreach science communication project which was produced together with the University of Bern's Support Center for ICT-Aided…
Rocketvax News The next-generation live-attenuated vaccine, named OTS-228, has demonstrated significant safety and efficacy in pre-clinical studies, marking a hopeful advancement in the fight against COVID-19. Developed by researchers from Institute…
While the active site of ribosomes is evolutionary extremely conserved, other parts of cytosolic ribosomes did change to adapt to an organism's need. One one hand these concerns ribosomal proteins, on the other hand expansion in the ribosomal RNA.…
The Pillai lab wrote a review in which they summarise the role of N6-methyladenosine (m6A) and involved proteins, writers, erasers and readers, in the mammalian germline affecting gametogenesis and fertility, and the potential to treat reproductive…
Cholera disease is caused by the bacterium Vibrio cholerae. The seventh pandemic V. cholerae strains possess two molecular immune systems to eliminate invasive mobile genetic elements, which are thought to be crucial for its evolutionary success.…
University of Zurich News Article / News Artikel Universität Zürich A distinct signaling pathway called TNF-alpha drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF-alpha…
