News Listing

FMI News Article
The protection of genome integrity of germ cells is essential for animal fertility. Researchers from the Grosshans group characterized a defense mechanism against selfish genetic elements in the C. elegans germline. They identified a protein processing mechanism that controls the…

ETHZ D-BIOL News Article
In a recent "BMC Bioinformatics" paper the Corn group (IMHS) in collaboration with the Genome Engineering & Measurement Lab (GEML) developed PnB Designer, a web-based application for the design of guide RNAs for prime and base editing.

Link to the D-BIOL News Article

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A recent "Nature Chemical Biology" paper by the Allain group (IMBB) in collaboration with the Jeschke (DCHAB-PC) and Klotzsch (HEST & Humboldt) labs demonstrates a novel method to simultaneously quantify FUS in the droplets and characterize FUS structurally both in the dispersed and condensed…

The Corn lab developed "scarless" Cas9-based reagents to create and reverse a prevalent mutation which is associated with myeloproliferative neoplasms. Introducing the mutation into systems to study the disease should better reproduce the disease phenotype than previoulsy developed overexpression…

In vitro reconstituting U1snRNP suitable for NMR studies, allowed the Allain lab and collaborators to study its disordered parts and their interactions. They used Cryo-EM and SANS to complement their NMR findings. Their paper entitled "An in vitro reconstituted U1 snRNP allows the study of the…