National Center of Competence
in Research, RNA & Disease

News Listing

Functional miRNAs in mESCs Identified

The Ciaudo lab in collaboration with the Gatfield and Aebersold labs applied an integrative approach to determine which transcripts in mouse Embryonic Stem Cells are regulated directly by miRNAs and found that less than 10% are, opposite to previous approaches that estimated that up to 60% are.…

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Methods & Protocols on Alternative Splicing

A new "Methods in Molecular Biology" book was published on "Alternative Splicing: Methods and Protocols". The book was edited by Oriane Mauger and Peter Scheiffele from the University of Basel and features seven articles from NCCR member & associate member labs including one alumni lab.

The…

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Sars-CoV-2 RNA Polymerase: Optimal Analogue Concentration & Rate Limiting Nucleotide Determined

Hasan Vatandaslar was during his PhD studies in the Stoffel lab doing a research stay in the Tusch lab supported by the NCCR Lab Exchange Program, when the Covid-19 pandemic hit New York. He decided to switch his research focus to SARS-CoV-2 and continued to work in the lab. He described this…

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Cytosolic Aggregates Restrict Retrotransposition

Approximately one fifth of the human genome is made up of Long Interspersed Elements 1 (Line 1), which need to be prevented from spreading and moving through the genome; a process called retrotransposition. An open question was how this is achieved in very early mouse development during which two…

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Q&A with Maria Hondele

A Q&A with Maria Hondele, who is tenure track assistant professor at the University of Basel's Biozentrum, was published in Molecular Cell. Since February 2021, Maria Hondele is an associate member of the NCCR RNA & Disease.

Link to Q&A in Molecular Cell

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Single molecule imagining reveals new features of the UPR Activation

A paper with co-corresponding authors Franka Voigt (Chao lab, FMI) and Tomás Aragón (University of Navarra) provides new insights into non-canonical splicing of XBP1 by IRE1a required for the Unfolded Protein Response (UPR).Tthrough using single molecule live cell imagining approaches, the…

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Linker Protein of the Trypanosome TAC Complex Characterized

The Schneider, Warscheid and Vögtle lab characterized the linker protein p166 of the Tripartite Attachment Complex (TAC) in Trypanosomes. Trypanosomes have only one mitochondrium with a single genome called kinetoplast DNA (kDNA). The TAC, which links the kDNA to the base of the flagellum over the…

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Airway Culture Model to Study MERS-CoV Infection

The Dijkman and Thiel labs with collaborators established an epithelial cell culture model to study MERS-CoV. As the natural host of the zoonotic MERS Coronavirus are camelids, they suded cells from camels and lamas to establish their model. They could demonstrate that in this model the replication…

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Tackling Sickle Cell Disease with CRISPR

A publication with co-corresponding author Jacob Corn reports that mutated B-globin can be corrected with CRISPR in patient derived cells ex vivo and then injected into mice for analysis. This analysis revealed that over 30% of the hematopoietic stem cells that engrafted over a longer term carried…

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Mitochondrial Quality Control Mechansim Discovered

The Schneider lab in collaboration with the Warscheid and Ochsenreiter labs, discovered a new quality control mechanism in Trypanosomes. The mechanims can get triggered when the translocase subunit responsible for mitochondrial import of hydrophobic proteins gets ablated and leads to the proteasomal…

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