How does metabolism intersect with fundamental principles in translation regulation? And how does introducing a pro-differentiation proteome lead to cures in highly malignant mouse models via a "Reverse Yamanaka-Effect"? Read more about this recent…
ETH News Article / Artikel Thanks to CRISPR/Cas technology, researchers can precisely edit genetic material to treat hereditary diseases. To achieve this, they need to identify undesirable cuts in the genome at an early juncture. Pioneer Fellow Lilly…
Unlike other organisms, trypanosomes have only one translocases of the inner membrane (TIM) complex to import proteins across the inner mitochondrial membrane. The Schneider lab and collaborators now investigated one of its subunits, TbTim20, which…
Up-frameshift 1 (UPF1) is an essential protein and key to Nonsense Mediated Decay (NMD). UPF1 is an ATP-dependent RNA helicase and was shown to shuttle between the cytoplasm and the nucleus, with most of the protein residing in the cytoplasm. The…
ETH News Article / Artikel Do cells contain a mechanism that decides on their fates? Researchers at ETH Zurich have demonstrated in a new study that large clusters of molecules determine a cell’s future.
On September 6, 2025, we had the pleasure of presenting our booth, “RNA – Master of Versatility”, at the ‘Nacht der Forschung’ (Science Night) at the University of Bern. It was a fantastic evening full of curiosity, engaging questions, and lively…
Led by the Polacek group, researchers looked into the roles in cancer of one of the four human noncoding vault RNAs, vault RNA 1-2. They found in human hepatocellular carcinoma cell lines that vault RNA 1-2 contributes to several hallmarks of cancer…
Datasets to train machine learning algorithms to predict the translational dynamics and predict the correlation between a given mRNA level and proteins produced from them have relied on data generated on libraries of synthetic mRNAs. These synthetic…
The Ban lab in collaboration with the Deuerling and Shan labs could elucidate in human cells the mechanism of co-translational N-myristoylation. This modification affects the function and localization of the modified proteins and the responsible…
