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Diabetes and fatty liver disease can be caused by hyperglycemia which in turn can be caused by obesity. However, the linking mechanism is unkown. The lab of Michael Hall and collaborators could now show that a high-fat diet in mice leads to the loss of Hexokinase 2 in adipose tissue. This loss…

The Pillai lab found that in vivo mouse MIWI cleaves targets containing mismatches at certain positions while in vitro such targets are not sliced. In addition they discovered that not all PIWI slicing targets become mature piRNAs. Their findings were published in the article "In vivo PIWI slicing…

When nutrients are limited, cells keep a pool of dormant ribosomes which get activated, when nutrients become available again. The lab of Michael Hall now found that in yeast the protein Stm1 controls the formation of dormant ribosomes. When nutrients become availalbe again TORC1 phosporylates Stm1…

The ciliate Paramecium tetraurelia's genome enodes many PIWI-clade proteins, of many of which the function is unkown. One of them is called Ptiwi08, which is expressed only shortly during development. The Nowacki lab found out that Ptiwi08 degrades untranslated mRNAs at this developmental transition…

Jonathan Hall wrote a perspective article which in his view the future directions for medicinal chemistry in the field of Oligonucleotide Therapeutics are. The article entitled " Future directions for medicinal chemistry in the field of oligonucleotide therapeutics " has been published in RNA.

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