News Listing

The fourteenth edition of the NCCR RNA & Disease Newsletter -The Messenger has been published.

Click here to read the Messenger.

The Chao lab's paper on "Structure of the human C9orf72-SMCR8 complex reveals a multivalent protein interaction architecture" has just been published in PLoS Biology.

Abstract
A major cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) spectrum disorder is the…

Press Release / Medienmitteilung / Communiqué de presse Universität Bern
A team of researchers from the Institute for Infectious Diseases (IFIK) at the University of Bern and the Institute of Virology and Immunology (IVI) have used a unique collection of advanced cell culture models of cells lining…

The Ban and Shan labs' insights into "Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle" and its regulation have been published in Cell Reports.

Highlights

  • Cryo-EM reveals the molecular features of the mammalian SRP targeting complexes
  • The fold…

FMI News Article
Long considered ‘junk’, non-coding RNAs have emerged as important regulators of diverse cellular processes, including the silencing of genes. Working in yeast, researchers from the Bühler group have identified more than 20 mutations that enable RNA-mediated gene silencing. The…

The Ruepp lab together with the Barabino, Dormann and Mühlemann labs determined the different protein and RNA interactome of soluble and phase-speparated FUS. Their findings have been published in Nucleic Acids in an article entitled "The phase separation-dependent FUS interactome reveals nuclear…

The NCCR RNA & Disease is participating in the #NCCRWomen campaign and will publish five portraits featuring researchers from our network this week!

The campaign in short: To celebrate the 50th anniversary of women obtaining the right to vote in Switzerland, all NCCRs currently in place across the…

Using an enhancer screen the Bühler identified new suppressors of RNA-mediated epigentic silencers. Their findings were published in PLOS Genetics in an article entitled "An enhancer screen identifies new suppressors of small-RNA-mediated epigenetic gene silencing".

Author summary
Besides silencing…

The Roignant and Soller labs in collaboration with other groups including the Jinek lab found that the E3 ubiquitin ligase Hakai stabilizes the m6A methylation machinery. Their article entitled "Hakai is required for stabilization of core components of the m6A mRNA methylation machinery" has been…

Using Cryo-EM, the Ban lab could visualize eight assembly intermediates of the human mitochondrial large ribosomal subunit and determined molecular structures for three of these. Their findings were published in Nature Communications in an article with the title "Stepwise maturation of the peptidyl…