Welcome to the Swiss National Center
of Competence in Research RNA & Disease

The role of RNA in disease mechanisms


News

rRNA Expansion Segment 7S Increases Translation Accuracy

Pro- and eukaryotic ribosomes contain very similar active centers, but eukaryotic ribosomes have a higher translational…
 

Binding Mode of Small Molecule Splice Modifiers to RNA

The Allain and Campagne labs previously elucidated the binding mode of the SMN-C5 splicing modifier molecule to its…
 

Feline Coronavirus Replicon System for Inhibitor Identification

Feline coronavirus causes feline infectious peritonitis a lethal disease killing cats worlwide. The Thiel and Tekes labs…
 

New Insights into Regulation of Translation and Stability of 5'TOP mRNAs

The Chao lab investigated by single-molecule translation site imagining the role that the proteins LARP1 and 4EBP1/2…
 

Review on Coronavirus Takeover of Host Cell Translation

After infecting a cell Corona viruses need to take control over it including its translational machinery. The Ban and…
 

Activation of Bacterial Immune System Sparta by DNA Target

The Swarts and Jinek labs could elucidate the structure of the prokaryotic immune system SPARTA in its monomeric…