The Mühlemann lab wrote a review on translational readthrough in eukaryotes. They discuss the factors that influence translational readthrough such as sequence context, tissue, age and others. They also summarize approaches to modulate readthrough…
Despite the widespread use of CRISPR-based genome editing nucleases in basic research and the clinic, Transcription Activator-Like Effector Nucleases (TALENs) are being applied in the clinic, and relatively little is known about their target…
The Gatfield (University of Lausanne) and Jonas (ETH Zürich) labs discovered that both PIN nuclease domains of SMG5 and SMG6 are required for efficient mRNA degradation by Nonsense-mediated decay. The PIN domain of SMG5 was considered to not be…
We congratulate Sebastian Leidel (DCBP, University of Bern) on being awarded the 2026 the RNA Society Mid-Career Award! According to their website, the RNA Society established in 2016 this award to recognize outstanding scientific achievements for…
FMI News Article Scientists at the FMI and the University of California-Santa Cruz have found that similar molecular machineries control daily circadian rhythms and developmental timing. Their work in worms shows that core timing systems can be…
Inhibiting ribosome biogenesis is a promising strategy for treating cancers. Despite the many factors involved that could represent potential drug targets only few inhibitors have been identified to date. To help this aim, the Kutay and Horvath labs…
Non-tuberculous mycobacteria are an emerging health threat and are difficult to treat due to their high resistance to antibiotics. Mycobacterium abcessus causes particularly difficult to treat infections with an estimated mortality of 50% over 15…
This paper in “Nature Chemistry” by the Allain Group (IBC) presents an NMR method to characterize condensates formed by disease-associated CAG-repeat RNA. The method uses water-detection, revealing that such condensates are semi-solid and contain…
How does metabolism intersect with fundamental principles in translation regulation? And how does introducing a pro-differentiation proteome lead to cures in highly malignant mouse models via a "Reverse Yamanaka-Effect"? Read more about this recent…
