FMI News Article
Thanks to their expertise in single-molecule imaging of RNAs, researchers from the group of Jeff Chao at the FMI helped to reveal the biological mechanism of a small molecule that restricts Ewing’s sarcoma cell growth. The study - published in Nature Chemical Biology - is further evidence that each step of the gene expression pathway may be druggable, and a great example of a Novartis-FMI collaboration.
A new druggable step in the gene expression pathway
A673 cells treated with JTE-607 have increased nucleoplasmic R-loop formation. Image: FMI Basel