A new druggable step in the gene expression pathway

A673 cells treated with JTE-607 have increased nucleoplasmic R-loop formation. Image: FMI Basel

FMI News Article
Thanks to their expertise in single-molecule imaging of RNAs, researchers from the group of Jeff Chao at the FMI helped to reveal the biological mechanism of a small molecule that restricts Ewing’s sarcoma cell growth. The study - published in Nature Chemical Biology - is further evidence that each step of the gene expression pathway may be druggable, and a great example of a Novartis-FMI collaboration.

Link to FMI News Article

Read the Publication in Nature Chemical Biology

Website Chao Lab