Joshua Mendell - NCCR RNA Seminar Series (BE)

Oxidative stress at telomeres triggers internal DNA loops, TRF1 dissociation, and TRF2-dependent R-loops
High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation
Comprehensive interrogation of synthetic lethality in the DNA damage response
Autophagy machinery as exploited by viruses
A functional screen uncovers circular RNAs regulating excitatory synaptogenesis in hippocampal neurons

Recent Preprints

Oligonucleotide-based PROTACs to Degrade RNA- and DNA-Binding Proteins
In vivo single-cell CRISPR screening for microproteins identifies a critical ribosomal component
Identification of new interactors of eIF3f by endogenous proximity-dependent biotin labelling in human muscle cells.
Proximity determines donor candidacy during DNA double-stranded break homology directed repair
Double-stranded RNA responses, neoantigen presentation and suppression of hepatocellular carcinoma through NMD inhibition via endonuclease SMG6