Jonathan Hall together with PhD students of his group wrote a review in which they look back at the history of Oligonucleotide Drugs, assess the present state and take a glimpse into the future. Their article "Medicinal Chemistry of Oligonucleotide Drugs-Milestones of the Past and Visions for the Future" has been published in the May edition of Chimia which is dedicated to the topic of Medicinal Chemistry.
Abstract
The oligonucleotide therapeutics field has blossomed in recent years, with thirteen approved drugs today and the promise of accelerated growth in coming years. Much of the progress in this field is due to advances in the medicinal chemistry of oligonucleotides,combined with a judicious choice of molecular targets and disease areas. In this perspective, we describe the growth of this new class of drugs highlighting selected milestones in oligonucleotide medicinal chemistry.
Read the Article in Chimia (Open Access)
Abstract, figure and title from Hall et al. (2022) Chimia published under a CC BY 4.0 license.