Disclaimer: This page includes all publications by NCCR member labs.

Publications

Most Recent

  • M. Saurer, D.J.F. Ramrath, M. Niemann, S. Calderaro, C. Prange, S. Mattei, A. Scaiola,  A. Leitner, P. Bieri, E.K. Horn, M. Leibundgut, D. Boehringer, A. Schneider and N. Ban (2019) Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery Science, 365(6458), 1144-1149
    Pubmed
  • R.D. Luteijn, S.A. Zaver, B.G. Gowen, S.K. Wyman, N.E. Garelis, L. Onia, S.M. McWhirter, G.E. Katibah, J.E. Corn, J.J. Woodward and D.H. Raulet (2019) SLC19A1 transports immunoreactive cyclic dinucleotides Nature, Epub ahead of print
    Pubmed
  • L.J.T. Kaaij, F. Mohn, R.H. van der Weide, E. de Wit E and M. Bühler (2019) The ChAHP Complex Counteracts Chromatin Looping at CTCF Sites that Emerged from SINE Expansions in Mouse Cell,178(6),1437-1451.e14
    Pubmed
  • J. Xue, E. Scotti and M. Stoffel (2019) CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic Beta Cells Cell Rep, 28(11), 2892-2904.e7
    Pubmed
  • A. Kumar, M. Clerici, L.M. Muckenfuss, L.A. Passmore and M. Jinek (2019) Mechanistic insights into mRNA 3'-end processing Curr Opin Struct Biol, Epub ahead of print
    Pubmed
  • C.E. Dumeau, Monfort A, L. Kissling, D.C Swarts, M. Jinek and A. Wutz (2019) Introducing gene deletions by mouse zygote electroporation of Cas12a/Cpf1 Transgenic Res, Epub ahead of print
    Pubmed
  • M. Mendel and R.S. Pillai (2019) Nxf3: a middleman with the right connections for unspliced piRNA precursor export Genes Dev, 33(17-18):1095-1097
    Pubmed
  • M. Weisser and N. Ban (2019) Extensions, Extra Factors, and Extreme Complexity: Ribosomal Structures Provide Insights into Eukaryotic Translation Cold Spring Harb Perspect Biol, 11(9), pii:a032367
    Pubmed

2019

  • M. Saurer, D.J.F. Ramrath, M. Niemann, S. Calderaro, C. Prange, S. Mattei, A. Scaiola,  A. Leitner, P. Bieri, E.K. Horn, M. Leibundgut, D. Boehringer, A. Schneider and N. Ban (2019) Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery Science, 365(6458), 1144-1149
    Pubmed
  • R.D. Luteijn, S.A. Zaver, B.G. Gowen, S.K. Wyman, N.E. Garelis, L. Onia, S.M. McWhirter, G.E. Katibah, J.E. Corn, J.J. Woodward and D.H. Raulet (2019) SLC19A1 transports immunoreactive cyclic dinucleotides Nature, Epub ahead of print
    Pubmed
  • L.J.T. Kaaij, F. Mohn, R.H. van der Weide, E. de Wit E and M. Bühler (2019) The ChAHP Complex Counteracts Chromatin Looping at CTCF Sites that Emerged from SINE Expansions in Mouse Cell,178(6),1437-1451.e14
    Pubmed
  • J. Xue, E. Scotti and M. Stoffel (2019) CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic Beta Cells Cell Rep, 28(11), 2892-2904.e7
    Pubmed
  • A. Kumar, M. Clerici, L.M. Muckenfuss, L.A. Passmore and M. Jinek (2019) Mechanistic insights into mRNA 3'-end processing Curr Opin Struct Biol, Epub ahead of print
    Pubmed
  • C.E. Dumeau, Monfort A, L. Kissling, D.C Swarts, M. Jinek and A. Wutz (2019) Introducing gene deletions by mouse zygote electroporation of Cas12a/Cpf1 Transgenic Res, Epub ahead of print
    Pubmed
  • M. Mendel and R.S. Pillai (2019) Nxf3: a middleman with the right connections for unspliced piRNA precursor export Genes Dev, 33(17-18):1095-1097
    Pubmed
  • M. Weisser and N. Ban (2019) Extensions, Extra Factors, and Extreme Complexity: Ribosomal Structures Provide Insights into Eukaryotic Translation Cold Spring Harb Perspect Biol, 11(9), pii:a032367
    Pubmed
  • D. Homolka and R.S. Pillai (2019) An RNA exporter that enforces a no-export policy Nat Struct Mol Biol, Epub ahead of print
    Pubmed
  • T. Hagen, A.L. Malinowska, H.L. Lightfoot, M. Bigatti and J. Hall (2019) Site-Specific Fluorophore Labeling of Guanosines in RNA G-Quadruplexes ACS Omega 4(5), 8472-8479
    Pubmed
  • G. Bottoni, A. Katarkar, B. Tassone, S. Ghosh, A. Clocchiatti, S. Goruppi, P. Bordignon, P. Jafari, F. Tordini, T. Lunardi, W. Hoetzenecker, V. Neel, J. Lingner and G. Paolo Dotto (2019) CSL controls telomere maintenance and genome stability in human dermal fibroblasts Nat Commun, 10(1),3884
    Pubmed
  • M. Diether, Y. Nikolaev, F.H. Allain and U. Sauer (2019) Systematic mapping of protein-metabolite interactions in central metabolism of Escherichia coli Mol Syst Biol, 15 (8), e9008
    Pubmed
  • E.I. Kessi-Pérez, F. Salinas, A. González, Y. Su, J.M. Guillamón, M.N. Hall, L.F. Larrondo and C. Martínez (2019) KAE1 Allelic Variants Affect TORC1 Activation and Fermentation Kinetics in Saccharomyces cerevisiae Front Microbiol, 10, 1686
    Pubmed
  • F. Voigt, J. Eglinger and J.A. Chao (2019) Quantification of mRNA Turnover in Living Cells: A Pipeline for TREAT Data Analysis Methods Mol Biol, 2038,75-88
    Pubmed
  • X. Ding, S. Willenborg, W. Bloch, S.A. Wickström, P. Wagle, S. Brodesser, A. Roers, A. Jais, J.C. Brüning, M.N. Hall, M.A. Rüegg and S.A. Eming (2019) Epidermal mTORC2 controls lipid synthesis and filaggrin processing in epidermal barrier formation J Allergy Clin Immunol, Epub ahead of print
    Pubmed
  • M. Gamerdinger, K. Kobayashi, A. Wallisch, S.G. Kreft, C. Sailer, R. Schlömer, N. Sachs, A. Jomaa, F. Stengel, N. Ban and E. Deuerling (2019) Early Scanning of Nascent Polypeptides inside the Ribosomal Tunnel by NAC Mol Cell, Epub ahead of print
    Pubmed
  • Y. Nikolaev, N. Ripin, M. Soste, P. Picotti, D. Iber and F.H. Allain (2019) Systems NMR: single-sample quantification of RNA, proteins and metabolites for biomolecular network analysis Nat Methods, 16(8), 743-749
    Pubmed
  • T. Welte, A.C. Tuck, P. Papasaikas, S.H. Carl, M. Flemr, P. Knuckles, A. Rankova, M. Bühler and H. Großhans (2019) The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1 Genes Dev, Epub ahead of print
    Pubmed
  • R.R. Pandey and R.S. Pillai (2019) Counting the Cuts: MAZTER-Seq Quantifies m(6)A Levels Using a Methylation-Sensitive Ribonuclease Cell,178(3), 515-517
    Pubmed
  • J.L Huot, S. Shikha and A. Schneider (2019) Inducible orthogonal aminoacylation demonstrates that charging is required for mitochondrial tRNA import in Trypanosoma brucei Sci Rep, 9(1), 10836
    Pubmed
  • M. Feretzaki, P. Renck Nunes and J. Lingner (2019) Expression and differential regulation of human TERRA at several chromosome ends RNA, Epub ahead of print
    Pubmed
  • H.L. Lightfoot, T. Hagen, N.J. Tatum and J. Hall (2019) The diverse structural landscape of quadruplexes FEBS Lett, Epub ahead of print
    Pubmed
  • A. Riba, N. Di Nanni, N. Mittal, E. Arhné, A. Schmidt and M. Zavolan (2019) Protein synthesis rates and ribosome occupancies reveal determinants of translation elongation rates Proc Natl Acad Sci U S A, Epub ahead of print
    Pubmed
  • S. Kabir, J. Cidado, C. Andersen, C. Dick, P.C. Lin, T. Mitros, H. Ma, S.H. Baik, M.A. Belmonte, L. Drew and J.E. Corn (2019) The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells Elife, pii: e44288
    Pubmed
  • A.J. Gruber and M. Zavolan (2019) Alternative cleavage and polyadenylation in health and disease Nat Rev Genet Epub ahead of print
    Pubmed
  • A. Leitner, G. Dorn and F.H. Allain (2019) Combining Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) Spectroscopy for Integrative Structural Biology of Protein-RNA Complexes Cold Spring Harb Perspect Biol 11(7), pii: a032359
    Pubmed
  • N. Ranjan and S.A. Leidel (2019) The epitranscriptome in translation regulation: mRNA and tRNA modifications as the two sides of the same coin? FEBS Lett Epub ahead of print
    Pubmed
  • J. Carlevaro-Fita, L. Liu, Y. Zhou, S. Zhang, P. Chouvardas, R. Johnson and J. Li  (2019) LnCompare: gene set feature analysis for human long non-coding RNAs Nucleic Acids Res, Epub ahead of print
    Pubmed
  • D. Benjamin and M.N. Hall (2019) Lactate jump-starts mTORC1 in cancer cells EMBO Rep, Epub ahead of print
    Pubmed
  • A. Cléry, L. Gillioz, C.K.X. Nguyen and F. H.-T. Allain (2019) A Step-by-Step Guide to Study Protein-RNA Interactions Chimia 73(6), 406-414
    Pubmed
  • S. Shikha, R. Brogli, A. Schneider and N. Polacek (2019) tRNA Biology in Trypanosomes Chimia 73(6), 395-405
    Pubmed
  • M. Tusup, L.E. French, M. De Matos, D. Gatfield, T. Kundig and S. Pascolo (2019) Design of in vitro Transcribed mRNA Vectors for Research and Therapy Chimia 73(6):391-394
    Pubmed
  • T. Afroz, M. Pérez-Berlanga and M. Polymenidou (2019) Structural Transition, Function and Dysfunction of TDP-43 in Neurodegenerative Diseases Chimia 73(6), 380-390
    Pubmed
  • L. Contu, S. Steiner, V. Thiel and O. Mühlemann (2019) The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence Chimia 73(6),374-379
    Pubmed
  • P. Röthlisberger, C. Berk C and J. Hall (2019) RNA Chemistry for RNA Biology Chimia 73(6), 368-373
    Pubmed
  • J.A. Schröder and P.E. Jullien (2019) The Diversity of Plant Small RNAs Silencing Mechanisms Chimia 73(6), 362-367
    Pubmed
  • E. Maciel and I.M. Mansuy (2019) Extracellular Vesicles and their miRNA Cargo: A Means of Communication between Soma and Germline in the Mammalian Reproductive System Chimia, 73(6), 356-361
    Pubmed
  • O. Mühlemann and F. H.-T. Allain (2019) Editorial Chimia 73(6), 353
    Pubmed
  • V. Schlösser and J. Hall (2019) Labeling microRNA precursors for Dicer assays Anal Biochem, Epub ahead of print
    Pubmed
  • B. Trinh B, M. Hepprich, M.J. Betz, T. Burkard, C. Cavelti-Weder, E. Seelig, F. Meienberg, D.V. Kratschmar, F. Beuschlein, M. Reincke, A. Odermatt, M.N. Hall, M.Y. Donath and M.M. Swierczynska (2019) Treatment of Primary Aldosteronism with mTORC1 Inhibitors J Clin Endocrinol Metab, Epub ahead of print
    Pubmed
  • J. Barman-Aksözen, F. Halloy, P.S. Iyer, D. Schümperli, A.E. Minder, J. Hall, E.I. Minder and X. Schneider-Yin (2019) Delta-aminolevulinic acid synthase 2 expression in combination with iron as modifiers of disease severity in erythropoietic protoporphyria Mol Genet Metab, Epub ahead of print
    Pubmed
  • X.X. Maurer-Alcalá and M. Nowacki (2019) Evolutionary origins and impacts of genome architecture in ciliates Ann N Y Acad Sci, Epub ahead of print
    Pubmed
  • J.W. Hegge, D.C. Swarts, S.D. Chandradoss, T.J. Cui, J. Kneppers, M. Jinek, C. Joo and J. van der Oost (2019) DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute Nucleic Acids Res, Epub ahead of print
    Pubmed
  • T.M. Sirey, K. Roberts, W. Haerty, O. Bedoya-Reina, S. Rogatti-Granados, J.Y. Tan, N. Li, L.C. Heather, R.N. Carter, S. Cooper, A.J. Finch, J. Wills, N.M Morton, A.C. Marques and C.P. Ponting (2019) The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity Elife 8, e45051
    Pubmed
  • C.G. Ricci, J.S. Chen, Y. Miao, M. Jinek, J.A. Doudna, J.A. McCammon and G. Palermo (2019) Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics ACS Cent Sci 5(4), 651-662
    Pubmed
  • F. Voigt, J.V. Gerbracht, V. Boehm, I. Horvathova, J. Eglinger, J.A. Chao and N.H. Gehring (2019) Detection and quantification of RNA decay intermediates using XRN1-resistant reporter transcripts Nat Protoc Epub ahead of print
    Pubmed
  • B. Wienert, S.K. Wyman, C.D. Richardson, C.D. Yeh, P. Akcakaya, M.J. Porritt, M. Morlock, J.T. Vu, K.R. Kazane, H.L. Watry, L.M. Judge, B.R. Conklin, M. Maresca and J.E. Corn (2019) Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq Science 364(6437), 286-289
    Pubmed
  • V. Castelo-Szekely, M. De Matos, M. Tusup, S. Pascolo, J. Ule and D. Gatfield (2019) Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock Nucleic Acids Res Epub ahead of print
    Pubmed
  • P. Denichenko, M. Mogilevsky, A. Cléry, T. Welte, J. Biran, O. Shimshon, G.D. Barnabas, M. Danan-Gotthold, S. Kumar, E. Yavin, E.Y. Levanon, F.H. Allain, T. Geiger, G. Levkowitz and R. Karni (2019) Specific inhibition of splicing factor activity by decoy RNA oligonucleotides Nat Commun 10(1):1590
    Pubmed
  • B.J. Walder, C. Berk, W.C. Liao, A.J. Rossini, M. Schwarzwälder, U. Pradere, J. Hall, A. Lesage, C. Copéret and L. Emsley (2019) One- and Two-Dimensional High-Resolution NMR from Flat Surfaces ACS Cent Sci 5(3),515-523
    Pubmed
  • F. Boneberg, T. Brandmann, L. Kobel, J. van den Heuvel, K. Bargsten, L. Bammert, U. Kutay and M. Jinek (2019) Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14 in ribosome biogenesis RNA Epub ahead of print
    Pubmed
  • F. Aeschimann, A. Neagu, M. Rausch and H. Grosshans (2019) let-7 coordinates the transition to adulthood through a single primary and four secondary targets Life Sci Alliance 2(2),pii: e201900335
    Pubmed
  • L. Duempelmann, F. Mohn, Y. Shimada, D. Oberti, A. Andriollo, S. Lochs and M. Bühler (2019) Inheritance of a Phenotypically Neutral Epimutation Evokes Gene Silencing in Later Generations Mol Cell Epub ahead of print
    Pubmed
  • B. Blasco-Moreno, L. de Campos-Mata, R. Böttcher, J. García-Martínez, J. Jungfleisch, D.D. Nedialkova, S. Chattopadhyay, M.E. Gas, B. Oliva, J.E. Pérez-Ortín, S.A. Leidel, M. Choder and J. Díez (2019)The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins Nat Commun 10(1),1298
    Pubmed
  • D. Jacob, K. Thüring, A. Galliot, V. Marchand, A. Galvanin, A. Ciftci, K. Scharmann, M. Stock, J.Y. Roignant, S.A. Leidel, Y. Motorin, R. Schaffrath, R. Klassen and M. Helm (2019) Absolute quantification of noncoding RNA by microscale thermophoresis Angew Chem Int Ed Engl Epub ahead of print
    Pubmed
  • D. Mayer, F.F. Damberger, M. Samarasimhareddy, M. Feldmueller, Z. Vuckovic, T. Flock, B. Bauer, E. Mutt, F. Zosel, F.H.T. Allain, J. Standfuss, G.F.X. Schertler, X. Deupi, M.E. Sommer, M. Hurevich, A. Friedler and D.B. Veprintsev (2019 )Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation Nat Commun 10(1),1261
    Pubmed
  • J. Carlevaro-Fita and R. Johnson (2019) Global Positioning System: Understanding Long Noncoding RNAs through Subcellular Localization Mol Cell 73(5), 869-883
    Pubmed
  • R. Esposito, N. Bosch, A. Lanzós, T. Polidori, C. Pulido-Quetglas and R. Johnson (2019) Hacking the Cancer Genome: Profiling Therapeutically Actionable Long Non-coding RNAs Using CRISPR-Cas9 Screening Cancer Cell Epub ahead of print
    Pubmed
  • K. Suda, A. Kaneko, M. Shimobayashi, A. Nakashima, M. Tatsuya, M.N. Hall and T. Ushimaru (2019) TORC1 regulates autophagy induction in response to proteotoxic stress in yeast and human cells Biochem Biophys Res Commun 511(2), 434-439
    Pubmed
  • S. Subramania, L.M. Gagné, S. Campagne, V. Fort, J. O'Sullivan, K. Mocaer, M. Feldmüller, J.Y. Masson, F.H.T. Allain, S.M. Hussein and M.É. Huot (2019) SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing Nucleic Acids Res Epub ahead of print
    Pubmed
  • N. Ripin, J. Boudet, M.M. Duszczyk, A. Hinniger, M. Faller, M. Krepl, A. Gadi, R.J. Schneider, J. Šponer J, N.C. Meisner-Kober and F.H. Allain (2019) Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM Proc Natl Acad Sci U S A 116(8):2935-2944
    Pubmed
  • A. Sendoel, D. Subasic, L. Ducoli, M. Keller, E. Michel, I. Kohler, K.D. Singh, X. Zheng, A. Brümmer, J. Imig, S. Kishore, Y. Wu, A. Kanitz, A. Kaech, N. Mittal, A.M. Matia-González, A.P. Gerber, M. Zavolan, R. Aebersold, J. Hall, F.H. Allain and M.O. Hengartner (2019) MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans Cell Death Differ Epub ahead of print
    Pubmed
  • V. Paunescu, M. Zavolan and T. Oprea (2019) In memoriam: Francisc Schneider (1933-2017) J Cell Mol Med Epub ahead of print
    Pubmed
  • L. Kissling, A. Monfort, D.C. Swarts, A. Wutz and M. Jinek (2019) Preparation and electroporation of Cas12a/Cpf1-guide RNA complexes for introducing large gene deletions in mouse embryonic stem cells Methods Enzymol 616,241-263
    Pubmed
  • A. Kanitz, A.P. Syed, K. Kaji and M. Zavolan (2019) Conserved regulation of RNA processing in somatic cell reprogramming BMC Genomics 20(1),100
    Pubmed
  • Y. Miyake, J.J. Keusch, L. Decamps, H. Ho-Xuan, S. Iketani, H. Gut, U. Kutay, A. Helenius and Y. Yamauchi (2019) Influenza virus uses transportin 1 for vRNP debundling during cell entry Nat Microbiol 4(4),578-586
    Pubmed
  • N. Savic, F.C. Ringnalda, C. Berk, K. Bargsten, J. Hall, M. Jinek and G. Schwank (2019) In vitro Generation of CRISPR-Cas9 Complexes with Covalently Bound Repair Templates for Genome Editing in Mammalian Cells Bio Protoc 9(1), pii: e3136
    Pubmed
  • J.H. Wilbertz, F. Voigt, I. Horvathova, G. Roth, Y. Zhan and J.A. Chao (2019) Single-Molecule Imaging of mRNA Localization and Regulation during the Integrated Stress Response Mol Cell 73(5),946-958.e7
    Pubmed
  • D.C. Swarts and M. Jinek (2019) Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a Mol Cell 73(3),589-600.e4
    Pubmed
  • J. Li, I. Vázquez-García, K. Persson, A. González, J.X. Yue, B. Barré, M.N. Hall, A. Long, J. Warringer, V. Mustonen and G. Liti (2019) Shared molecular targets confer resistance over short and long evolutionary timescales Mol Biol Evol Epub ahead of print
    Pubmed
  • R. Fricker, R. Brogli, H. Luidalepp, L. Wyss, M. Fasnacht, O. Joss, M. Zywicki, M. Helm, A. Schneider, M. Cristodero and N. Polacek (2019) A tRNA half modulates translation as stress response in Trypanosoma brucei Nat Commun10(1):118
    Pubmed
  • S. Campagne, M. Krepl, J. Sponer and F.H. Allain (2019 ) Combining NMR Spectroscopy and Molecular Dynamic Simulations to Solve and Analyze the Structure of Protein-RNA Complexes Methods Enzymol 614,393-422
    Pubmed
  • J. Boudet, J.C. Devillier, T. Wiegand, L. Salmon, B.H. Meier, G. Lipps and F.H. Allain (2019) A Small Helical Bundle Prepares Primer Synthesis by Binding Two Nucleotides that Enhance Sequence-Specific Recognition of the DNA Template Cell 176(1-2):154-166.e13
    Pubmed
  • L. Pereira, F. Aeschimann, C. Wang, H. Lawson, E. Serrano-Saiz, D.S. Portman, H. Grosshans and O. Hobert (2019) Timing mechanism of sexually dimorphic nervous system differentiation Elife 8, pii: e42078
    Pubmed
  • M.M. Swierczynska, M.J. Betz, M. Colombi, E. Dazert, P. Jenö, S. Moes, C. Pfaff, K. Glatz, M. Reincke, F. Beuschlein, M.Y. Donath and M.N. Hall (2019) Proteomic Landscape of Aldosterone-Producing Adenoma Hypertension 73(2),469-480
    Pubmed
  • F.E. Loughlin, P.J. Lukavsky, T. Kazeeva, S. Reber, E.M. Hock, M. Colombo, C. Von Schroetter, P. Pauli, A. Cléry, O. Mühlemann, M. Polymenidou, M.D. Ruepp and F.H. Allain (2019)The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity Mol Cell 73(3), 490-504.e6
    Pubmed
  • J. Carlevaro-Fita, T. Polidori, M. Das, C. Navarro, T.I. Zoller and R. Johnson (2019) Ancient exapted transposable elements promote nuclear enrichment of human long noncoding RNAs Genome Res 29(2), 208-222
    Pubmed
  • L. Champion, S. Pawar, N. Luithle, R. Ungricht and U. Kutay (2019) Dissociation of membrane-chromatin contacts is required for proper chromosome segregation in mitosis Mol Biol Cell 30(4),427-440
    Pubmed
  • F. Laferrière, Z. Maniecka, M. Pérez-Berlanga, M. Hruska-Plochan, L. Gilhespy, E.M. Hock, U. Wagner, T. Afroz, P.J. Boersema, G. Barmettler, S.C. Foti, Y.T. Asi, A.M. Isaacs, A. Al-Amoudi, A. Lewis, H. Stahlberg, J. Ravits, F. De Giorgi, F. Ichas, E. Bezard, P. Picotti, T. Lashley and M. Polymenidou (2019) TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates Nat Neurosci 22(1), 65-77
    Pubmed

2018

  • M. Bodak, J. Yu and C. Ciaudo (2018) Regulation of LINE-1 Elements by miR-128 Is Not Conserved in Mouse Embryonic Stem Cells Front Genet 9,683
    Pubmed
  • G. Palermo, J.S. Chen, C.G. Ricci, I. Rivalta, M. Jinek, V.S. Batista, J.A. Doudna and J.A. McCammon (2018) Key role of the REC lobe during CRISPR-Cas9 activation by 'sensing', 'regulating', and 'locking' the catalytic HNH domain Q Rev Biophys 51, e91
    Pubmed
  • D. Benjamin, D. Robay, S.K. Hindupur, J. Pohlmann, M. Colombi, M.Y. El-Shemerly, S.M. Maira, C. Moroni, H.A. Lane and M.N. Hall (2018) Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells Cell Rep 25(11), 3047-3058.e4
    Pubmed
  • J.A. Chao and T. Lionnet (2018) Imaging the Life and Death of mRNAs in Single Cells Cold Spring Harb Perspect Biol 10(12), a032086
    Pubmed
  • A. Jawaid, R. Khan, M. Polymenidou and P.E. Schulz (2018) Disease-modifying effects of metabolic perturbations in ALS/FTLD Mol Neurodegener 13(1), 63
    Pubmed 
  • A. Schneider (2018) Mitochondrial  protein import in trypanosomatids: Variations on a theme or fundamentally different? PLoS Pathog 14(11), e1007351
    Pubmed
  • N. Ban (2018) Thomas Steitz 1940-2018 Nat Struct Mol Biol, Epub ahead of print
    Pubmed
  • A. Kroupova, A. Ivascu, M.M. Reimão-Pinto, S.L. Ameres and M. Jinek (2018) Structural basis for acceptor RNA substrate selectivity of the 3' terminal uridylyl transferase Tailor Nucleic Acids Res., Epub ahead of print
    Pubmed
  • D. Mossmann, S. Park and M.N. Hall (2018) mTOR signalling and cellular metabolism are mutual determinants in cancer Nat Rev Cancer, Epub ahead of print
    Pubmed
  • M. Vancová, B. Schimanski B, L.R. Cadena, J. Heller, T. Bílý, D. Potešil, C. Eichenberger, H. Bruce, S. Oeljeklaus, B. Warscheid, Z. Zdráhal, A. Schneider, J. Lukeš and H. Hashimi (2018) The Diverged Trypanosome MICOS Complex as a Hub for Mitochondrial Cristae Shaping and Protein Import Curr Biol 28(21), 3393-3407 
    Pubmed
  • A. C. Title, S. J. Hong, N. D. Pires, L. Hasenohrl, S. Godbersen, N. Stokar-Regenscheit, D. P. Bartel and M. Stoffel (2018) Genetic dissection of the miR-200-Zeb1 axis reveals its importance in tumor differentiation and invasion Nature Communications 9(1), 4671
    Pubmed
  • A. Singh, A. Vancura, R. K. Woycicki, D. J. Hogan, A. G. Hendrick and M. Nowacki (2018) Determination of the presence of 5-methylcytosine in Paramecium tetraurelia PLoS One 13(10), e0206667
    Pubmed
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  • F. Lampert, D. Stafa, A. Goga, M. V. Soste, S. Gilberto, N. Olieric, P. Picotti, M. Stoffel and M. Peter (2018) The multi-subunit GID/CTLH E3 ligase promotes proliferation and targets the transcription factor Hbp1 for degradation Elife 7, e35528 
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  • V. Ostapcuk, F. Mohn, S.H. Carl, A. Basters, D. Hess, V. Iesmantavicius, L. Lampersberger, M. Flemr, A. Pandey, N.H. Thoma, J. Betschinger and M. Bühler (2018) Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes Nature 557(7707), 739-743
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  • S. Käser, I. Glauser, J. Rettig and A. Schneider (2018) The pseudo-dimeric tyrosyl-tRNA synthetase of T. brucei aminoacylates cytosolic and mitochondrial tRNA(Tyr) and requires both monomeric units for activity Mol Biochem Parasitol, 221, 52-55
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  • F. Michelini, A.P. Jalihal, S. Francia, C. Meers, Z.T. Neeb, F. Rossiello, U. Gioia, J. Aguado, C. Jones-Weinert, B. Luke, G. Biamonti, M. Nowacki, F. Storici, P. Carninci, N.G. Walter and F. d'Adda di Fagagna (2018) From "Cellular" RNA to "Smart" RNA: Multiple Roles of RNA in Genome Stability and Beyond Chem Rev,  118(8), 4365-4403
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  • G. Brancati and H. Grosshans (2018) An interplay of miRNA abundance and target site architecture determines miRNA acticity and specificity Nucleic Acids Res, Epub ahead of print
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  • K. Kobayashi, A. Jomaa, J.H. Lee, S. Chandrasekar, D. Boehringer, S.O. Shan and N. Ban (2018) Structure of a prehandover mammalian ribosomal SRP*SRP receptor targeting complex Science, 360(6386), 323-327
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  • S.K. Hindupur, M. Colombi, S.R. Fuhs, M.S. Matter, Y. Guri, K. Adam, M. Cornu, S. Piscuoglio, C.K.Y. Ng, C. Betz, D. Liko, L. Quagliata, S. Moes, P. Jenoe, L.M. Terracciano, M. H. Heim, T. Hunter and M.N. Hall (2018) The protein histidine phosphatase LHPP is a tumour suppressor Nature, 555(7698), 678-682
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  • C. Hoehener, I. Hug and M. Nowacki (2018) Dicer-like Enzymes with Sequence Cleavage Preferences Cell, 173(1), 234-247 e7
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  • P. Knuckles, T. Lence, I.U. Haussmann, D. Jacob, N. Kreim, S.H. Carl, I. Masiello, T. Hares, R. Villasenor, D. Hess, M.A. Andrade-Navarro, M. Biggiogera, M. Helm, M. Soller, M. Bühler and J.Y. Roignant (2018) Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m(6)A machinery component Wtap/Fl(2)d Genes Dev, 32(5-6), 415-429
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  • C. Dimitrakopoulos, S. Kumar Hindupur, L. Hafliger, J. Behr, H. Montazeri, M.N. Hall and N. Beerenwinkel (2018) Network-based integration of multi-omics data for prioritizing cancer genes Bioinformatics, Epub ahead of print
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  • T. Brandmann, H. Fakim, Z. Padamsi, J.Y. Youn, A.C. Gingras, M.R. Fabian and Jinek, M. (2018) Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes EMBO J, 37(7), e97869
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  • G.R. Bantug, M. Fischer, J. Grahlert, M.L. Balmer, G. Unterstab, L. Develioglu, R. Steiner, R., L. Zhang, A. S. H. Costa, P. M. Gubser, A. V. Burgener, U. Sauder, J. Loliger, R. Belle, S. Dimeloe, J. Lötscher, A. Jauch, M. Recher, G. Honger, M.N. Hall, P. Romero, C. Frezza and C. Hess (2018) Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8(+) T Cells Immunity, 48(3), 542-555 e6
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  • M. de la Mata and H. Grosshans (2018) Turning the table on miRNAs Nat Struct Mol Biol, 25(3), 195-197
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  • E. Michel, O. Duss and F.H. Allain (2018) An Integrated Cell-Free Assay to Study Translation Regulation by Small Bacterial Noncoding RNAs Methods Mol Biol, 1737, 177-195 
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  • A. Scaiola, C. Pena, M. Weisser, D. Böhringer, M. Leibundgut, P. Klingauf-Nerurkar, S. Gerhardy, V.G. Panse and N. Ban (2018) Structure of a eukaryotic cytoplasmic pre-40S ribosomal subunit EMBO J 37(7), e98499 
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  • G. Masliah, C. Maris, S.L. König, M. Yulikov, F. Aeschimann, A.L. Malinowska, J. Mabille, J. Weiler, A. Holla, J. Hunziker, N. Meisner-Kober, B. Schuler, G. Jeschke and  F.H. Allain (2018) Structural basis of siRNA recognition by TRBP double-stranded RNA binding domains EMBO J, 37(6), e97089  
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  • A. Hoffmann, S. Käser, M. Jakob, S. Amodeo, C. Peitsch, J. Tyc, S. Vaughan, B. Zuber, A. Schneider and T. Ochsenreiter (2018) Molecular model of the mitochondrial genome segregation machinery in Trypanosoma brucei Proc Natl Acad Sci U S A, 115(8), E1809-E1818
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  • E. Stuttfeld, C.H. Aylett, S. Imseng, D. Boehringer, A. Scaiola, E. Sauer, M.N. Hall, T. Maier and N. Ban (2018) Architecture of the human mTORC2 core complex Elife, 7, e33101
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  • G. Glousker and J. Lingner (2018) When Telomerase Causes Telomere Loss Dev Cell, 44(3), 281-283
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  • Schneider A. (2018) Dihydrofolate reductase and membrane translocation: evolution of a classic experiment: Classic landmark papers, irrespective of their age, can teach students how best science is practiced and inspire new experiments EMBO Rep, 19(3),  e45692
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  • R.P. Ngondo, D. Cirera-Salinas, J. Yu, H. Wischnewski, M. Bodak, S. Vandormael-Pournin, A. Geiselmann, R. Wettstein, J. Luitz, M. Cohen-Tannoudji and C. Ciaudo (2018) Argonaute 2 Is Required for Extra-embryonic Endoderm Differentiation of Mouse Embryonic Stem Cells Stem Cell Reports, 10(2), 461-476
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  • M. Habibian, M. Yahyaee-Anzahaee, M. Lucic, E. Moroz, N. Martin-Pintado, L.D. Di Giovanni, J. C. Leroux, J. Hall, C. Gonzalez and M.J. Damha (2018) Structural properties and gene-silencing activity of chemically modified DNA-RNA hybrids with parallel orientation Nucleic Acids Res, 46(4), 1614-23
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  • M. Clerici, M. Faini, L.M. Muckenfuss, R. Aebersold and M. Jinek (2018) Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex Nat Struct Mol Biol, 25(2), 135-138
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  • P. Nicholson, A. Gkratsou, C. Josi, M. Colombo and O. Mühlemann (2018) Dissecting the functions of SMG5, SMG7 and PNRC2 in nonsense-mediated mRNA decay of human cells RNA, 24(4), 557-573
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  • P. Bieri, B.J. Greber and N. Ban (2018) High-resolution structures of mitochondrial ribosomes and their functional implications Curr Opin Struct Biol, 49, 44-53
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  • J. Willi, P. Küpfer, D. Evéquoz, G. Fernandez, A. Katz, C. Leumann and N. Polacek (2018) Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center Nucleic Acids Res, 46(4), 1945-1957
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  • N.B. Milev and D. Gatfield (2018) Circadian Clocks and UPR: New Twists as the Story Unfolds Dev Cell, 44(1), 7-9
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  • F. Voigt, J. Eglinger and J. A. Chao (2018) Detection of the First Round of Translation: The TRICK Assay Methods Mol Biol, 1649, 373-384
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  • W. Ahmed and J. Lingner (2018) Impact of oxidative stress on telomere biology Differentiation 99,21-27
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  • M. Vlot, J. Houkes, S. J. A. Lochs, D. C. Swarts, P. Zheng, T. Kunne, P. Mohanraju, C. Anders, M. Jinek, J. van der Oost, M. J. Dickman and S. J. J. Brouns (2018) Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR-Cas effector complexes Nucleic Acids Res, 46(2), 873-885
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  • E. Sonnleitner, A. Wulf, S. Campagne, X. Y. Pei, M. T. Wolfinger, G. Forlani, K. Prindl, L. Abdou, A. Resch, F. H. Allain, B. F. Luisi, H. Urlaub and U. Blasi (2018) Interplay between the catabolite repression control protein Crc, Hfq and RNA in Hfq-dependent translational regulation in Pseudomonas aeruginosa Nucleic Acids Res, 46(3), 1470-1485
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  • Z. T. Neeb and M. Nowacki (2018) RNA-mediated transgenerational inheritance in ciliates and plants Chromosoma, 127(1), 19-27
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  • S. Reber, J. Mechtersheimer, S. Nasif, J. A. Benitez, M. Colombo, M. Domanski, D. Jutzi, E. Hedlund and M. D. Ruepp (2018) CRISPR-Trap: A clean approach for the generation of gene knockouts and gene replacements in human cells Mol Biol Cell, 29(2), 75-83
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  • S. Nasif, L. Contu and O. Mühlemann (2018) Beyond quality control: The role of nonsense-mediated mRNA decay (NMD) in regulating gene expression Semin Cell Dev Biol, 75, 78-87 
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  • J. Singer, H. J. Ruscheweyh, A. L. Hofmann, T. Thurnherr, F. Singer, N. C. Toussaint, C. K. Y. Ng, S. Piscuoglio, C. Beisel, G. Christofori, R. Dummer, M. N. Hall, W. Krek, M.P. Levesque, M. G. Manz, H. Moch, A. Papassotiropoulos, D. J. Stekhoven, P. Wild, T. Wust, B. Rinn and N. Beerenwinkel (2018) NGS-pipe: a flexible, easily extendable, and highly configurable framework for NGS analysis Bioinformatics, 34(1), 107-108
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2017

  • S. Käser, M. Willemin, F. Schnarwiler, B. Schimanski, D. Poveda-Huertes, S. Oeljeklaus, B. Haenni, B. Zuber, B. Warscheid, C. Meisinger and A. Schneider (2017) Biogenesis of the mitochondrial DNA inheritance machinery in the mitochondrial outer membrane of Trypanosoma brucei PLoS Pathog, 13(12), e1006808
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  • F. Voigt, H. Zhang, X.A. Cui, D. Triebold, A.X. Liu, J. Eglinger, E.S. Lee, J. A. Chao and A. F. Palazzo (2017) Single-Molecule Quantification of Translation-Dependent Association of mRNAs with the Endoplasmic Reticulum Cell Rep, 21(13), 3740-3753
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  • M. Zavolan M. and A. Kanitz (2017) RNA splicing and its connection with other regulatory layers in somatic cell reprogramming Curr Opin Cell Biol, 52, 8-13
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  • M. Clerici, M. Faini, R. Aebersold and M. Jinek (2017) Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex Elife, 6, e33111
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  • K. Essig, D. Hu, J. C. Guimaraes, D. Alterauge, S. Edelmann, T. Raj, J. Kranich, G. Behrens, A. Heiseke, S. Floess, J. Klein, A. Maiser, S. Marschall, M. Hrabe de Angelis, H. Leonhardt, C. F. Calkhoven, E. Noessner, T. Brocker, J. Huehn, A. B. Krug, M. Zavolan, D. Baumjohann and V. Heissmeyer (2017) Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells Immunity, 47 (6), 1067-1082 e12
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  • Y. Guri, M. Colombi, E. Dazert, S. K. Hindupur, J. Roszik, S. Moes, P. Jenoe, M. H. Heim, I. Riezman, H. Riezman and M. N. Hall (2017) mTORC2 Promotes Tumorigenesis via Lipid Synthesis Cancer Cell, 32 (6), 807-823 e12
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  • G. Palermo, C. G. Ricci, A. Fernando, R. Basak, M. Jinek, I. Rivalta, V. S. Batista and J. A. McCammon (2017) Protospacer Adjacent Motif-Induced Allostery Activates CRISPR-Cas9 J Am Chem Soc 139(45), 16028-16031
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  • S. Berry, S. Rosa, M. Howard, M. Bühler and C. Dean (2017) Disruption of an RNA-binding hinge region abolishes LHP1-mediated epigenetic repression Genes Dev, 31 (21), 2115-2120
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  • F. Tang, P. Zhang, P. Ye, C. A. Lazarski, Q. Wu, I. L. Bergin, T. P. Bender, M. N. Hall, Y. Cui, L. Zhang, T. Jiang, Y. Liu and P. Zheng (2017) A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice Elife, 6, e32497
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  • M. Zavolan and B. R. Graveley (2017) RNAs: dynamic and mutable Genome Biol, 18 (1), 226
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  • J. Barman-Aksözen, P. Cwiek, V. B. Bansode, F. Koentgen, J. Trub, P. Pelczar, P. Cinelli, X. Schneider-Yin, D. Schümperli and E. I. Minder (2017) Modelling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice Dis Model Mech, 10(3), 225-233
    Pubmed
  • A. J. Thompson, S. Metzger, M. Lochner and M. D. Ruepp (2017) The binding orientation of epibatidine at alpha7 nACh receptors Neuropharmacology, 116(), 421-428
    Pubmed
  • S. Fitter, M. P. Matthews, S. K. Martin, J. Xie, S. S. Ooi, C. R. Walkley, J. D. Codrington, M. A. Ruegg, M. N. Hall, C. G. Proud, S. Gronthos and A. C. Zannettino (2017) mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation Mol Cell Biol, 37(7),
    Pubmed
  • M. Polymenidou and D. W. Cleveland (2017) Biological Spectrum of Amyotrophic Lateral Sclerosis Prions Cold Spring Harb Perspect Med, 7(11),
    Pubmed
  • R. Gumienny, D. J. Jedlinski, A. Schmidt, F. Gypas, G. Martin, A. Vina-Vilaseca and M. Zavolan (2017) High-throughput identification of C/D box snoRNA targets with CLIP and RiboMeth-seq Nucleic Acids Res, 45(5), 2341-2353
    Pubmed
  • P. Bieri, M. Leibundgut, M. Saurer, D. Boehringer and N. Ban (2017) The complete structure of the chloroplast 70S ribosome in complex with translation factor pY EMBO J, 36(4), 475-486
    Pubmed
  • A. Harsman and A. Schneider (2017) Mitochondrial protein import in trypanosomes: Expect the unexpected Traffic, 18(2), 96-109
    Pubmed

2016

  • J. Gebetsberger, L. Wyss, A. M. Mleczko, J. Reuther and N. Polacek (2016) A tRNA-derived fragment competes with mRNA for ribosome binding and regulates translation during stress RNA Biol, Epub ahead of print
    Pubmed
  • Y. Guri and M. N. Hall (2016) mTOR Signaling Confers Resistance to Targeted Cancer Drugs Trends Cancer, 2(11), 688-697
    Pubmed
  • J. Plassais, L. Lagoutte, S. Correard, M. Paradis, E. Guaguere, B. Hedan, A. Pommier, N. Botherel, M. C. Cadiergues, P. Pilorge, D. Silversides, M. Bizot, M. Samuels, C. Arnan, R. Johnson, C. Hitte, G. Salbert, A. Mereau, P. Quignon, T. Derrien and C. Andre (2016) A Point Mutation in a lincRNA Upstream of GDNF Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies PLoS Genet, 12(12), e1006482
    Pubmed
  • D. Benjamin, M. Colombi, S. K. Hindupur, C. Betz, H. A. Lane, M. Y. El-Shemerly, M. Lu, L. Quagliata, L. Terracciano, S. Moes, T. Sharpe, A. Wodnar-Filipowicz, C. Moroni and M. N. Hall (2016) Syrosingopine sensitizes cancer cells to killing by metformin Sci Adv, 2(12), e1601756
    Pubmed
  • E. Aeby, W. Ahmed, S. Redon, V. Simanis and J. Lingner (2016) Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase Cell Rep, 17(12), 3107-3114
    Pubmed
  • M. Berge, S. Campagne, J. Mignolet, S. Holden, L. Theraulaz, S. Manley, F. H. Allain and P. H. Viollier (2016) Modularity and determinants of a (bi-)polarization control system from free-living and obligate intracellular bacteria Elife, 5, e20640
    Pubmed
  • A. Harsman, S. Oeljeklaus, C. Wenger, J. L. Huot, B. Warscheid and A. Schneider (2016) The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins Nat Commun, 7, 13707
    Pubmed
  • Y. Shimada, F. Mohn and M. Bühler (2016) The RNA-induced transcriptional silencing complex targets chromatin exclusively via interacting with nascent transcripts Genes Dev, 30(23), 2571-2580
    Pubmed
  • E. Gasser, H. C. Johannssen, T. Rulicke, H. U. Zeilhofer and M. Stoffel (2016) Foxa1 is essential for development and functional integrity of the subthalamic nucleus Sci Rep, 6, 38611
    Pubmed
  • J. C. Guimaraes and M. Zavolan (2016) Patterns of ribosomal protein expression specify normal and malignant human cells Genome Biol, 17(1), 236
    Pubmed
  • R. Denzler, S. E. McGeary, A. C. Title, V. Agarwal, D. P. Bartel and M. Stoffel (2016) Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression Mol Cell, 64(3), 565-579
    Pubmed
  • U. Brykczynska, E. Pecho-Vrieseling, A. Thiemeyer, J. Klein, I. Fruh, T. Doll, C. Manneville, S. Fuchs, M. Iazeolla, M. Beibel, G. Roma, U. Naumann, N. Kelley, E. J. Oakeley, M. Mueller, B. Gomez-Mancilla, M. Bühler, E. Tabolacci, P. Chiurazzi, G. Neri, T. Bouwmeester, F. P. Di Giorgio and B. D. Fodor (2016) CGG Repeat-Induced FMR1 Silencing Depends on the Expansion Size in Human iPSCs and Neurons Carrying Unmethylated Full Mutations Stem Cell Reports, 7(6), 1059-1071
    Pubmed
  • M. Bolten, C. L. Delley, M. Leibundgut, D. Boehringer, N. Ban and E. Weber-Ban (2016) Structural Analysis of the Bacterial Proteasome Activator Bpa in Complex with the 20S Proteasome Structure, 24(12), 2138-2151
    Pubmed
  • X. Ding, W. Bloch, S. Iden, M. A. Ruegg, M. N. Hall, M. Leptin, L. Partridge and S. A. Eming (2016) mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation Nat Commun, 7, 13226
    Pubmed
  • G. Palermo, Y. Miao, R. C. Walker, M. Jinek and J. A. McCammon (2016) Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations ACS Cent Sci, 2(10), 756-763
    Pubmed
  • D. R. Driscoll, S. A. Karim, M. Sano, D. M. Gay, W. Jacob, J. Yu, Y. Mizukami, A. Gopinathan, D. I. Jodrell, T. R. Evans, N. Bardeesy, M. N. Hall, B. J. Quattrochi, D. S. Klimstra, S. T. Barry, O. J. Sansom, B. C. Lewis and J. P. Morton (2016) mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer Cancer Res, 76(23), 6911-6923
    Pubmed
  • M. M. Reimao-Pinto, R. A. Manzenreither, T. R. Burkard, P. Sledz, M. Jinek, K. Mechtler and S. L. Ameres (2016) Molecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila EMBO J, 35(22), 2417-2434
    Pubmed
  • M. B. Mobin, S. Gerstberger, D. Teupser, B. Campana, K. Charisse, M. H. Heim, M. Manoharan, T. Tuschl and M. Stoffel (2016) The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation Nat Commun, 7, 12848
    Pubmed
  • Q. Fu, R. R. Pandey, N. A. Leu, R. S. Pillai and P. J. Wang (2016) Mutations in the MOV10L1 ATP Hydrolysis Motif Cause piRNA Biogenesis Failure and Male Sterility in Mice Biol Reprod, 95(5), 103
    Pubmed
  • E. Moroz, S. H. Lee, K. Yamada, F. Halloy, S. Martinez-Montero, H. Jahns, J. Hall, M. J. Damha, B. Castagner and J. C. Leroux (2016) Carrier-free Gene Silencing by Amphiphilic Nucleic Acid Conjugates in Differentiated Intestinal Cells Mol Ther Nucleic Acids, 5(9), e364
    Pubmed
  • D. Ustianenko, J. Pasulka, Z. Feketova, L. Bednarik, D. Zigackova, A. Fortova, M. Zavolan and S. Vanacova (2016) TUT-DIS3L2 is a mammalian surveillance pathway for aberrant structured non-coding RNAs EMBO J, 35(20), 2179-2191
    Pubmed
  • M. N. Hall (2016) TOR and paradigm change: cell growth is controlled Mol Biol Cell, 27(18), 2804-6
    Pubmed
  • T. S. Miki, S. H. Carl, M. B. Stadler and H. Grosshans (2016) XRN2 Autoregulation and Control of Polycistronic Gene Expresssion in Caenorhabditis elegans PLoS Genet, 12(9), e1006313
    Pubmed
  • D. Bar-Yaacov, I. Frumkin, Y. Yashiro, T. Chujo, Y. Ishigami, Y. Chemla, A. Blumberg, O. Schlesinger, P. Bieri, B. Greber, N. Ban, R. Zarivach, L. Alfonta, Y. Pilpel, T. Suzuki and D. Mishmar (2016) Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates PLoS Biol, 14(9), e1002557
    Pubmed
  • P. Sledz and M. Jinek (2016) Structural insights into the molecular mechanism of the m6A writer complex Elife, 5, e18434
    Pubmed
  • L. Bammert, S. Jonas, R. Ungricht and U. Kutay (2016) Human AATF/Che-1 forms a nucleolar protein complex with NGDN and NOL10 required for 40S ribosomal subunit synthesis Nucleic Acids Res, 44(20), 9803-9820
    Pubmed
  • M. Menzi, U. Pradère, Y. Wang, M. Fischer, F. Baumann, M. Bigatti and J. Hall (2016) Site-Specific Labeling of MicroRNA Precursors: A Structure-Activity Relationship Study Chembiochem, 17(21), 2012-2017
    Pubmed
  • M. Roos, U. Pradere, R. P. Ngondo, A. Behera, S. Allegrini, G. Civenni, J. A. Zagalak, J. R. Marchand, M. Menzi, H. Towbin, J. Scheuermann, D. Neri, A. Caflisch, C. V. Catapano, C. Ciaudo and J. Hall (2016) A Small-Molecule Inhibitor of Lin28 ACS Chem Biol, 11(10), 2773-2781
    Pubmed
  • N. Larburu, C. Montellese, M. F. O'Donohue, U. Kutay, P. E. Gleizes and C. Plisson-Chastang (2016) Structure of a human pre-40S particle points to a role for RACK1 in the final steps of 18S rRNA processing Nucleic Acids Res, 44(17), 8465-78
    Pubmed
  • E. M. Hock and M. Polymenidou (2016) Prion-like propagation as a pathogenic principle in frontotemporal dementia J Neurochem, 138 Suppl 1, 163-83
    Pubmed
  • S. Desy, J. Mani, A. Harsman, S. Käser and A. Schneider (2016) TbLOK1/ATOM19 is a novel subunit of the noncanonical mitochondrial outer membrane protein translocase of Trypanosoma brucei Mol Microbiol, 102(3), 520-529
    Pubmed
  • P. Odermatt, J. Trub, L. Furrer, R. Fricker, A. Marti and D. Schümperli (2016) Somatic therapy of a mouse SMA model with a U7 snRNA gene correcting SMN2 splicing Mol Ther, 24(10), 1797-1805
    Pubmed
  • S. Käser, S. Oeljeklaus, J. Tyc, S. Vaughan, B. Warscheid and A. Schneider (2016) Outer membrane protein functions as integrator of protein import and DNA inheritance in mitochondria Proc Natl Acad Sci U S A, 113(31), E4467-75
    Pubmed
  • E. C. Swart, V. Serra, G. Petroni and M. Nowacki (2016) Genetic Codes with No Dedicated Stop Codon: Context-Dependent Translation Termination Cell, 166(3), 691-702
    Pubmed
  • H. Lindsay, A. Burger, B. Biyong, A. Felker, C. Hess, J. Zaugg, E. Chiavacci, C. Anders, M. Jinek, C. Mosimann and M. D. Robinson (2016) CrispRVariants charts the mutation spectrum of genome engineering experiments Nat Biotechnol, 34(7), 701-2
    Pubmed
  • S. Campagne, S. Dintner, L. Gottschlich, M. Thibault, M. Bortfeld-Miller, A. Kaczmarczyk, A. Francez-Charlot, F. H. Allain and J. A. Vorholt (2016) Role of the PFXFATG[G/Y] Motif in the Activation of SdrG, a Response Regulator Involved in the Alphaproteobacterial General Stress Response Structure 24 (8),1237-47
    Pubmed
  • J. Kang, E. P. Kusnadi, A. J. Ogden, R. J. Hicks, L. Bammert, U. Kutay, S. Hung, E. Sanij, R. D. Hannan, K. M. Hannan and R. B. Pearson (2016) Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription Oncotarget, 7(31), 48887-48904
    Pubmed
  • A. J. Gruber, R. Schmidt, A. R. Gruber, G. Martin, S. Ghosh, M. Belmadani, W. Keller and M. Zavolan (2016) A comprehensive analysis of 3' end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on cleavage and polyadenylation Genome Res, 26(8), 1145-59
    Pubmed
  • J. M. Pröpster, F. Yang, S. Rabbani, B. Ernst, F. H. Allain and M. Schubert (2016) Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8 Proc Natl Acad Sci U S A, 113(29), E4170-9
    Pubmed
  • S. Reber, J. Stettler, G. Filosa, M. Colombo, D. Jutzi, S. C. Lenzken, C. Schweingruber, R. Bruggmann, A. Bachi, S. M. Barabino, O. Mühlemann and M. D. Ruepp (2016) Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants EMBO J, 35(14), 1504-21
    Pubmed
  • G. Martin and M. Zavolan (2016) Redesigning CLIP for efficiency, accuracy and speed Nat Methods, 13(6), 482-3
    Pubmed
  • O. Cohen-Fix and U. Kutay (2016) Editorial overview: The cell nucleus: Plastic, elastic and fantastic Curr Opin Cell Biol, 40, iv-v
    Pubmed
  • D. Albino, G. Civenni, C. Dallavalle, M. Roos, H. Jahns, L. Curti, S. Rossi, S. Pinton, G. D'Ambrosio, F. Sessa, J. Hall, C. V. Catapano and G. M. Carbone (2016) Activation of the Lin28/let-7 Axis by Loss of ESE3/EHF Promotes a Tumorigenic and Stem-like Phenotype in Prostate Cancer Cancer Res, 76(12), 3629-43
    Pubmed
  • M. Krepl, A. Clery, M. Blatter, F. H. Allain and J. Sponer (2016) Synergy between NMR measurements and MD simulations of protein/RNA complexes: application to the RRMs, the most common RNA recognition motifs Nucleic Acids Res, 44(13), 6452-70
    Pubmed
  • H. Jorjani, S. Kehr, D. J. Jedlinski, R. Gumienny, J. Hertel, P. F. Stadler, M. Zavolan and A. R. Gruber (2016) An updated human snoRNAome Nucleic Acids Res, 44(11), 5068-82
    Pubmed
  • E. D. Karousis, S. Nasif and O. Mühlemann (2016) Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact Wiley Interdiscip Rev RNA, 7(5), 661-82
    Pubmed
  • R. Ungricht and U. Kutay (2016) A Wounded Nucleus Needs ESCRT Service Dev Cell, 37(3), 202-4
    Pubmed
  • O. Mühlemann (2016) Spermatogenesis Studies Reveal a Distinct Nonsense-Mediated mRNA Decay (NMD) Mechanism for mRNAs with Long 3'UTRs PLoS Genet, 12(5), e1005979
    Pubmed
  • R. Ungricht, S. Pawar and U. Kutay (2016) An In Vitro Assay to Study Targeting of Membrane Proteins to the Inner Nuclear Membrane Methods Mol Biol, 1411, 461-77
    Pubmed
  • A. Burger, H. Lindsay, A. Felker, C. Hess, C. Anders, E. Chiavacci, J. Zaugg, L. M. Weber, R. Catena, M. Jinek, M. D. Robinson and C. Mosimann (2016) Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes Development, 143(11), 2025-37
    Pubmed
  • P. Janich, A. B. Arpat, V. Castelo-Szekely and D. Gatfield (2016) Analyzing the temporal regulation of translation efficiency in mouse liver Genom Data, 8, 41-4
    Pubmed
  • J. Carlevaro-Fita, A. Rahim, R. Guigo, L. A. Vardy and R. Johnson (2016) Cytoplasmic long noncoding RNAs are frequently bound to and degraded at ribosomes in human cells RNA, 22(6), 867-82
    Pubmed
  • H. Luidalepp, S. Berger, O. Joss, T. Tenson and N. Polacek (2016) Ribosome Shut-Down by 16S rRNA Fragmentation in Stationary-Phase Escherichia coli J Mol Biol, 428(10 Pt B), 2237-2247
    Pubmed
  • Y. V. Nikolaev, K. Kochanowski, H. Link, U. Sauer and F. H. Allain (2016) Systematic Identification of Protein-Metabolite Interactions in Complex Metabolite Mixtures by Ligand-Detected Nuclear Magnetic Resonance Spectroscopy Biochemistry, 55(18), 2590-600
    Pubmed
  • M. M. Swierczynska and M. N. Hall (2016) eIF4A moonlights as an off switch for TORC1 EMBO J, 35(10), 1013-4
    Pubmed
  • F. Grahammer, V. Nesterov, A. Ahmed, F. Steinhardt, L. Sandner, F. Arnold, T. Cordts, S. Negrea, M. Bertog, M. A. Ruegg, M. N. Hall, G. Walz, C. Korbmacher, F. Artunc and T. B. Huber (2016) mTORC2 critically regulates renal potassium handling J Clin Invest, 126(5), 1773-82
    Pubmed
  • B. J. Greber and N. Ban (2016) Structure and Function of the Mitochondrial Ribosome Annu Rev Biochem, 85, 103-132
    Pubmed
  • K. Drägert, I. Bhattacharya, M. N. Hall, R. Humar, E. Battegay and E. Haas (2016) Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue Biochem Biophys Res Commun, 473(1), 317-22
    Pubmed
  • R. Janowski, G. A. Heinz, A. Schlundt, N. Wommelsdorf, S. Brenner, A. R. Gruber, M. Blank, T. Buch, R. Buhmann, M. Zavolan, D. Niessing, V. Heissmeyer and M. Sattler (2016) Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40 Nat Commun, 7, 11032
    Pubmed
  • C. Anders, K. Bargsten and M. Jinek (2016) Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9 Mol Cell, 61(6), 895-902
    Pubmed
  • V. Olieric, T. Weinert, A. D. Finke, C. Anders, D. Li, N. Olieric, C. N. Borca, M. O. Steinmetz, M. Caffrey, M. Jinek and M. Wang (2016) Data-collection strategy for challenging native SAD phasing Acta Crystallogr D Struct Biol, 72(Pt 3), 421-9
    Pubmed
  • C. Schweingruber, P. Soffientini, M. D. Ruepp, A. Bachi and O. Mühlemann (2016) Identification of Interactions in the NMD Complex Using Proximity-Dependent Biotinylation (BioID) PLoS One, 11(3), e0150239
    Pubmed
  • V. Romeo and D. Schümperli (2016) Cycling in the nucleus: regulation of RNA 3' processing and nuclear organization of replication-dependent histone genes Curr Opin Cell Biol, 40, 23-31
    Pubmed
  • M. Bodak and C. Ciaudo (2016) Monitoring Long Interspersed Nuclear Element 1 Expression During Mouse Embryonic Stem Cell Differentiation Methods Mol Biol, 1400, 237-59
    Pubmed
  • J. Y. Tan and A. C. Marques (2016) miRNA-mediated crosstalk between transcripts: The missing "linc"? Bioessays 38(3),295-301
    Pubmed
  • U. Pradère and J. Hall (2016) Site-Specific Difunctionalization of Structured RNAs Yields Probes for microRNA Maturation Bioconjug Chem, 27(3), 681-7
    Pubmed
  • A. Jomaa, D. Boehringer, M. Leibundgut and N. Ban (2016) Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon Nat Commun, 7, 10471
    Pubmed
  • L. Zhang, B. O. Tschumi, I. C. Lopez-Mejia, S. G. Oberle, M. Meyer, G. Samson, M. A. Ruegg, M. N. Hall, L. Fajas, D. Zehn, J. P. Mach, A. Donda and P. Romero (2016) Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner Cell Rep, 14(5), 1206-17
    Pubmed
  • E. Dazert, M. Colombi, T. Boldanova, S. Moes, D. Adametz, L. Quagliata, V. Roth, L. Terracciano, M. H. Heim, P. Jenoe and M. N. Hall (2016) Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient Proc Natl Acad Sci U S A, 113(5), 1381-6
    Pubmed
  • H. Richter, I. Katic, H. Gut and H. Grosshans (2016) Structural basis and function of XRN2 binding by XTB domains Nat Struct Mol Biol, 23(2), 164-171
    Pubmed
  • V. Albert, K. Svensson, M. Shimobayashi, M. Colombi, S. Munoz, V. Jimenez, C. Handschin, F. Bosch and M. N. Hall (2016) mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue EMBO Mol Med, 8(3), 232-46
    Pubmed
  • O. Niewoehner and M. Jinek (2016) Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6 RNA, 22(3), 318-29
    Pubmed
  • B. J. Greber, S. Gerhardy, A. Leitner, M. Leibundgut, M. Salem, D. Boehringer, N. Leulliot, R. Aebersold, V. G. Panse and N. Ban (2016) Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation Cell, 164(1-2), 91-102
    Pubmed
  • C. H. Aylett, E. Sauer, S. Imseng, D. Boehringer, M. N. Hall, N. Ban and T. Maier (2016) Architecture of human mTOR complex 1 Science, 351(6268), 48-52
    Pubmed
  • Z. Yang, K. M. Chen, R. R. Pandey, D. Homolka, M. Reuter, B. K. Janeiro, R. Sachidanandam, M. O. Fauvarque, A. A. McCarthy and R. S. Pillai (2016) PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway Mol Cell, 61(1), 138-52
    Pubmed
  • M. Shimobayashi and M. N. Hall (2016) Multiple amino acid sensing inputs to mTORC1 Cell Res, 26(1), 7-20
    Pubmed
  • A. Neve, J. Trub, S. Saxena and D. Schümperli (2016) Central and peripheral defects in motor units of the diaphragm of spinal muscular atrophy mice Mol Cell Neurosci, 70, 30-41
    Pubmed
  • P. Shende, L. Xu, C. Morandi, L. Pentassuglia, P. Heim, S. Lebboukh, C. Berthonneche, T. Pedrazzini, B. A. Kaufmann, M. N. Hall, M. A. Ruegg and M. Brink (2016) Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy Cardiovasc Res, 109(1), 103-14
    Pubmed
  • B. Herkert, A. Kauffmann, S. Molle, C. Schnell, T. Ferrat, H. Voshol, J. Juengert, H. Erasimus, G. Marszalek, M. Kazic-Legueux, E. Billy, D. Ruddy, M. Stump, D. Guthy, M. Ristov, K. Calkins, S. M. Maira, W. R. Sellers, F. Hofmann, M. N. Hall and S. M. Brachmann (2016) Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition Cancer Res, 76(2), 390-402
    Pubmed
  • A. Brunschweiger, L. F. Gebert, M. Lucic, U. Pradere, H. Jahns, C. Berk, J. Hunziker and J. Hall (2016) Site-specific conjugation of drug-like fragments to an antimiR scaffold as a strategy to target miRNAs inside RISC Chem Commun (Camb), 52(1), 156-9
    Pubmed
  • J. Mani, C. Meisinger and A. Schneider (2016) Peeping at TOMs-Diverse Entry Gates to Mitochondria Provide Insights into the Evolution of Eukaryotes Mol Biol Evol, 33(2), 337-51
    Pubmed
  • K. Tugay, C. Guay, A. C. Marques, F. Allagnat, J. M. Locke, L. W. Harries, G. A. Rutter and R. Regazzi (2016) Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets Diabetologia, 59(1), 161-9
    Pubmed
  • R. Wettstein, M. Bodak and C. Ciaudo (2016) Generation of a Knockout Mouse Embryonic Stem Cell Line Using a Paired CRISPR/Cas9 Genome Engineering Tool Methods Mol Biol, 1341, 321-43
    Pubmed

2015

  • L. Badertscher, T. Wild, C. Montellese, L. T. Alexander, L. Bammert, M. Sarazova, M. Stebler, G. Csucs, T. U. Mayer, N. Zamboni, I. Zemp, P. Horvath. and U. Kutay (2015) Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells Cell Rep, 13 (12), 2879-91
    Pubmed
  • F. Aimi, S. Georgiopoulou, I. Kalus, F. Lehner, A. Hegglin, P. Limani, V. Gomes de Lima, A. R. M, M. N. Hall, N. Lindenblatt, E. Haas, E. J. Battegay and R. Humar (2015) Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult Sci Rep, 5, 17705
    Pubmed
  • O. Duss, N. Diarra Dit Konté and F. H. Allain (2015) Cut and Paste RNA for Nuclear Magnetic Resonance, Paramagnetic Resonance Enhancement, and Electron Paramagnetic Resonance Structural Studies Methods Enzymol, 565, 537-62
    Pubmed
  • E. Michel and F. H. Allain (2015) Selective Amino Acid Segmental Labeling of Multi-Domain Proteins Methods Enzymol, 565, 389-422
    Pubmed
  • L. Farine, M. Niemann, A. Schneider and P. Bütikofer (2015) Phosphatidylethanolamine and phosphatidylcholine biosynthesis by the Kennedy pathway occurs at different sites in Trypanosoma brucei Sci Rep, 5, 16787
    Pubmed
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2014

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