Pro- and eukaryotic ribosomes contain very similar active centers, but eukaryotic ribosomes have a higher translational accuracy than their prokaryotic counterparts. Also, they have acquired expansions in their proteins and rRNA which could underlie…
The Allain and Campagne labs previously elucidated the binding mode of the SMN-C5 splicing modifier molecule to its target RNA, a 5'-splice site in the SMN2 mRNA, and called its mode of action 5'-splice site bulge repair. They followed up this study…
Feline coronavirus causes feline infectious peritonitis a lethal disease killing cats worlwide. The Thiel and Tekes labs created a replicon system for drug screening which is itself non-infectious, and tested several compounds for their antiviral…
The Chao lab investigated by single-molecule translation site imagining the role that the proteins LARP1 and 4EBP1/2 play in translational repression in general of mRNAs and of mRNAs containing a 5'TOP motif whose translation is regulated by mTORC1.…
After infecting a cell Corona viruses need to take control over it including its translational machinery. The Ban and Karousis labs wrote a review in which they discuss how host cell translation is shut down, innate immune function suppressed, the…
The Swarts and Jinek labs could elucidate the structure of the prokaryotic immune system SPARTA in its monomeric inactive form and tetrameric active form, and could deduce mechanistically how binding to the DNA target leads to this activations. The…
The human genome is estimated to encode in small open reading frames more than 7000 microproteins. Their size makes it necessary to use dedicated approaches to study their functions which are still largely unknown. The Sendoel lab wrote a review on…
The Jeker and Zavolan labs assessed the 3'-UTR landscape from naive, activated, memory and regulatory CD4+ cells. After activation, the T cells undergo a rapid expansion, and during this period alternative polyadenylation events occured, which…
The Allain, Lipps and Wiegand labs using solution and solid state NMR could monitor in real time the kinetics of the initial dinucleotide formation by an archael DNA primase. Their experiments revealed also revealed that the helix bundle domain hands…
Premature stop codons are the cause of human genetic diseases, and could be treated if the ribosome could with a frameshift overcome the stop signal. The Nowacki lab could now in mammalian cells by expressing the eukaryotic release factor 1 from an…
