When two worlds meet: a protease that controls small RNA activity

DIC microscopy images of wild-type (top) and dpf-3 mutant (bottom) worms. Arrowhead indicate embryo, arrow indicate unfertilized oocytes in the uterus.

FMI News Article
The protection of genome integrity of germ cells is essential for animal fertility. Researchers from the Grosshans group characterized a defense mechanism against selfish genetic elements in the C. elegans germline. They identified a protein processing mechanism that controls the activity of small RNAs to achieve specific silencing of transposons while sparing endogenous genes.

Link to FMI News Article

Read the Publication in Molecular Cell

Website Grosshans Lab