Connecting two important processes in gene expression

Schematic diagram summarizing key findings: AVEN prevents ribosome stalls and the Ski complex eliminates transcripts if the stall is unresolved. Image: FMI Basel

FMI News Article
RNA decay plays a fundamental role in gene expression by controlling the quality and quantity of messenger RNAs. However, it has proved difficult to study and is still shrouded in mystery. Scientists from the Bühler group now uncovered key targets, components and functions of mammalian RNA decay pathways, and found that RNA decay is tightly connected to another crucial stage of gene expression: protein synthesis (translation).

Link to FMI News Article

Read the Publication in Molecular Cell (Open Access)

Website Bühler Lab

Website Gatfield Lab