Chromatin looping: CTCF versus ADNP

ADNP is not a loop extrusion barrier and masks underlying CTCF motifs.Loss of ADNP exposes additional CTCF binding sites and leads to novel loop anchor formation.Image: FMI Basel

FMI News Article
The organization of chromatin in the three-dimensional space is complex and requires the help of many proteins, including CTFC. Researchers from the group of Marc Bühler have identified a new player in the process: the transcription factor ADNP. In a recent study, they show that ADNP competes with CTFC, acting as a local modulator of chromatin looping.

Link to FMI News Article

Read the Publication in Cell

Website Bühler Lab