IRB News Article
A research team led by the Institute for Research in Biomedicine (IRB) in Bellinzona, affiliated to the Università della Svizzera italiana, has identified a molecular network required to balance the responses of human lymphocytes. The activities of these immune cells must be carefully regulated in order to ensure an effective defense of the organism. At the same time, the risk of damaging healthy tissues must be limited. Tissue damage may derive from excessive, unrestrained immune responses, and it can be at the basis of many chronic inflammatory diseases such as multiple sclerosis. With this work, the IRB researchers identified a molecular module involved in regulating the features that characterize highly proinflammatory and potentially pathogenic lymphocytes.