National Center of Competence
in Research, RNA & Disease

News Listing

Steve Pascolo and his research on mRNA vaccines in “NZZ Am Sonntag”

An article about Steve Pascolo and his contributions to the development of mRNA vaccines was published yesterday in “NZZ am Sonntag”. Steve Pascolo is group leader at the Dermatology Clinic of the University Hospital Zurich and head of the URPP Translational Cancer mRNA platform. He is an associate...

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Autism: How a gene alteration modifies social behavior

Press Release / Medienmitteilung Universität Basel
A team of researchers at the Biozentrum, University of Basel, has discovered a new connection between a genetic alteration and social difficulties related to autism: A mutation in the neuroligin-3 gene reduces the effect of the hormone oxytocin. In...

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National Research Programme (NRP) “Covid-19” funding by SNSF for NCCR RNA & Disease groups

Upon a mandate by the Federal Council, the SNSF launched a National Research Programme (NRP) to advance the understanding of the coronavirus disease 2019 (Covid-19). Among the 28 projects selected for funding, three projects include labs of the NCCR RNA & Disease network:

  • "Rapid Hybrid Structure...
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ATF4 regulates MYB to increase gamma-globin in response to loss of beta-globin

New paper by the Corn lab on "ATF4 regulates MYB to increase gamma-globin in response to loss of beta-globin" published in Cell Reports.

Highlights

  • Loss of beta-globin leads to upregulation of gamma-globin via altered ATF4 signaling
  • Reduced ATF4 decreases the levels of MYB and BCL11A
  • ATF4 induces...
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Immunoprotein impairs Sars-CoV-2

Press Release / Medienmitteilung Universität Bern
An international team with researchers of the Institute of Virology and Immunology (IVI) of the University of Bern and the Swiss Federal Food Safety and Veterinary Office (FSVO) showed that an endogenous protein prevents the virus from fusing with...

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A developmental clock with a checkpoint function

FMI News Article
The group of Helge Grosshans characterized the "C. elegans oscillator", over 3,700 genes that are rhythmically expressed during the larval development of C. elegans. They demonstrated the coupling of the oscillator with molting and got insights into how it is wired. Their findings...

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Structural insights into the mechanism of mitochondrial large subunit biogenesis

Another wonderful result of a fruitful NCCR RNA & Disease collaboration between the Ban at ETH Zurich and the Schneider Group at the University of Bern has just been published in Molecular Cell: Structure of two unique assembly intermediates, 28 identified assembly factors, supportive biochemical...

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Insights into mRNA degradation from single-molecule imaging in living cells

Review by the Chao lab in Current Opinion in Structural Biology entitled "Insights into mRNA degradation from single-molecule imaging in living cells ".

Highlights

  • TREAT allows for single-molecule imaging of RNA degradation in living cells.
  • P-bodes are not sites of mRNA degradation.
  • iSHiRLoC can be...
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Identification of a Nucleic Acid Binding Module of the Integrator Complex

The Integrator complex represses transcription of mRNAs and processes 3'-ends of non-coding RNAs. A new paper from the Jonas lab identifies a nucleic acid binding module of Integrator that brings RNA targets and nuclease subunit into proximity. The paper involved a collaboration with the NCCR RNA &...

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The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress

New paper by the Stoffel lab on "The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress" published in Cell Reports.

Highlights

  • JAZF1 localizes in the nucleus in high-glucose and metabolic stress conditions
  • JAZF1 mediates metabolic...
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