Work package 3: Translation
Translation is one of the most fundamental cellular processes, in which the genetic code is translated into proteins. Protein synthesis is conducted by a large ribonucleoprotein complex, the ribosome. In this work package we will study the ribosome by investigating its detailed structure and function, mechanisms of its maturation and assembly, as well as the regulation of translation initiation, ribosomal quality control and degradation, and how these processes are perturbed in various diseases. In addition to the cytosolic ribosome, we will also investigate components of the mitochondrial translational machinery including the mitochondrial ribosome of the parasitic protozoa Trypanosoma brucei.
Main research activities in this work package:• Eukaryotic ribosomes - their assembly, maturation and turnover
• Mitochondrial translation - a drug target against T. brucei and other trypanosomatids
• Regulation of translation and mRNA surveillance
Graphic source: Architecture of the large subunit of the mammalian mitochondrial ribosome, Prof. N. Ban Group, ETH
Participants:U. Kutay (Leader)
N. Ban (Co-leader)