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Press Release / Medienmitteilung Universität Basel

Author: System Administrator - Published At: 2017-12-14 13:32 - (30 Reads)
Liver cancer: Lipid synthesis promotes tumor formation
Lipid, also known as fat, is an optimal energy source and an important cell component. Much is required for the rapid and uncontrolled growth of cancer cells. Researchers from the Biozentrum of the University of Basel and from the University of Geneva have now discovered that the protein mTOR stimulates the production of lipids in liver tumors to satisfy the increased nutrient turnover and energy needs of cancer cells among other functions. This process has also been observed in patients with liver cancer as the scientists report in "Cancer Cell".
Link to Press Release(external link)
Leberkrebs: Fettproduktion fördert Tumorbildung
Fettverbindungen, auch Lipide genannt, sind optimale Energieträger und liefern wichtige Baustoffe für die Zelle. Schnell und unkontrolliert wachsende Krebszellen benötigen davon besonders viel. Forscher vom Biozentrum der Universität Basel sowie der Universität Genf haben nun herausgefunden, dass das Protein mTOR die Herstellung von Lipiden in Lebertumoren anregt, um unter anderem den gesteigerten Nährstoffumsatz und Energiebedarf der Krebszellen zu stillen. Auch bei Patienten mit Leberkrebs liess sich dieser Prozess beobachten, wie die Forscher in «Cancer Cell» berichten.
Link zur Medienmitteilung(external link)
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NCCR Newsletter No. 7

Author: System Administrator - Published At: 2017-12-04 17:09 - (75 Reads)
The Messenger - The NCCR RNA & Disease Newsletter
The seventh edition of the NCCR RNA & Disease Newsletter -The Messenger has been published:
Editorial
Norbert Polacek
Interview with Juan Valcárcel
"RNA should in a way be an icon of our culture."
Research highlights
It matters how we (or RNA) are born / Sending a second messenger
2nd NCCR RNA & Disease summer school
RNA & RNP architecture: from structure to function to disease
Public outreach Spreading scientific knowledge and passion
Bridging ideas CSM lab retreat
Announcements People, events, support grants and more
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CRG News Article / Medienmitteilung Universität Bern

Author: System Administrator - Published At: 2017-11-16 16:58 - (244 Reads)
A new method accelerates the mapping of genes in the “Dark Matter” of our DNA
  • Scientists at the Centre for Genomic Regulation (CRG) in Barcelona, have developed a new method, which improved the most important catalogue of genes -GENCODE-, including characterization of new genes in the DNA “Dark Matter”.
  • Their new method, published today in Nature Genetics, offers a way of mapping genes in a more accurate, faster and cheaper way.
Link to Press Release(external link)

Gene in der «dunklen Materie» der DNA besser identifizieren

Eine neue Methode erlaubt es, Gene schneller, präziser und günstiger zu identifizieren. Auch Gene in der «dunklen Materie» unserer DNA können so besser bestimmt werden, wie eine internationale Studie zeigt. Daran war auch das Department for Biomedical Research (DBMR) der Universität Bern beteiligt.

Link zur Medienmitteilung(external link)

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FMI News Article

Author: System Administrator - Published At: 2017-11-07 16:38 - (242 Reads)
An RNA TREAT for Halloween

Jeff Chao, Junior group leader at the FMI, and his group developed a sophisticated method to measure mRNA degradation in single cells. They developed a fluorescent biosensor that allows the distinction of intact transcripts and degradation intermediates. This novel method, known as TREAT, nicely complements the method they developed earlier, called TRICK, that measures protein translation.

Click here to read the whole FMI News Article(external link)
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EMBO Young Investigators: Jeffrey Chao and Magdalini Polymenidou

Author: System Administrator - Published At: 2017-11-07 16:31 - (294 Reads)
Congratulations to Jeffrey Chao(FMI Basel) and Magdalini Polymenidou (University of Zurich) on having been selected as EMBO Young Investigators!

EMBO Press Release(external link)

Website Chao Lab(external link)

Website Polymenidou Lab(external link)


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FMI News Article

Author: System Administrator - Published At: 2017-11-07 16:12 - (302 Reads)
The promoter sets the course for transcription termination

Helge Grosshans and his group at the Friedrich Miescher Institute for Biomedical Research (FMI) have identified two distinct modes of transcription termination – one dependent on, and one independent of, the highly conserved exoribonuclease XRN2. In a fruitful collaboration between wet-lab and computational biologists, they found that the promoter of a gene determines the mechanism for termination of its transcription.

Click here to read the whole FMI News Article(external link)
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Welcome to Steve Pascolo and Gerhard Schratt!

Author: System Administrator - Published At: 2017-11-07 16:04 - (264 Reads)
We would like to welcome Steve Pascolo (left picture) and Gerhard Schratt (right picture) who became associate members of the NCCR RNA & Disease.

Steve Pascolo is group leader at the Dermatology Clinic of the University Hospital Zurich and head of the URPP Tranlational Cancer mRNA platform(external link). The Pascolo group researches therapeutic applications of mRNA such as its use as a vaccine to treat cancer.

Gerhard Schratt is full professor for Systems Neuroscience at D-HEST, ETH Zurich.The Schratt laboratory investigates the functions of non-coding RNAs in neuronal development and plasticity.
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Welcome to Stefanie Jonas!

Author: System Administrator - Published At: 2017-09-13 17:47 - (514 Reads)
We would like to welcome Stefanie Jonas as junior principal investigator of the NCCR RNA & Disease! At the beginning of August Stefanie Jonas took up her position as assistant professor at the Institute of Molecular Biology & Biophysics, ETH Zurich.
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Press Release / Medienmitteilung Universität Basel

Author: System Administrator - Published At: 2017-09-13 12:39 - (337 Reads)
A Protein that Extends Life of Yeast Cells
To understand and control aging is the aspiration of many scientists. Researchers at the Biozentrum of the University of Basel have now discovered that the protein Gcn4 decreases protein synthesis and extends the life of yeast cells. Understanding how individual genes affect lifespan opens new ways to control the aging process and the occurrence of aging-related diseases. The results of this study have recently been published in “Nature Communications”.
Link to Press Release(external link)
Protein verlängert das Leben von Hefezellen
Den Prozess des Alterns verstehen und steuern zu können, ist Wunsch vieler Wissenschaftler. Forscher der Universität Basel haben nun herausgefunden, dass das Protein Gcn4 das Leben von Hefezellen verlängert, indem es die Produktion neuer Proteine herunterfährt. Das Verständnis, wie einzelne Gene die Lebensdauer beeinflussen, eröffnet neue Wege, den Alterungsprozess und damit auch das Auftreten altersbedingter Krankheiten zu steuern. Die Ergebnisse der Studie wurden nun in «Nature Communications» veröffentlicht.
Link zur Medienmitteilung(external link)
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Press Release / Medienmitteilung Universität Basel

Author: System Administrator - Published At: 2017-09-07 12:13 - (416 Reads)
Lasker Award for Michael N. Hall from the University of Basel
Professor Michael N. Hall from the Biozentrum of the University of Basel receives the Lasker Basic Medical Research Award 2017 – one of the most distinguished honors in biomedical research. With his discovery of the protein TOR, the biochemist was able to identify a key element in the regulation of cell growth, which is also responsible for the development of diseases such as cancer and diabetes.
Link to Press Release(external link)
Lasker-Award für Michael N. Hall von der Universität Basel
Professor Michael N. Hall vom Biozentrum der Universität Basel erhält den Lasker Basic Medical Research Award 2017 – eine der höchsten Auszeichnungen in der biomedizinischen Forschung. Der Biochemiker hat mit seiner Erforschung des Proteins TOR ein Schlüsselelement für die Steuerung des Zellwachstums entdeckt, das auch für die Entstehung von Krankheiten wie Krebs und Diabetes verantwortlich ist.
Link zur Medienmitteilung(external link)

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Press Release / Medienmitteilung Universität Bern

Author: System Administrator - Published At: 2017-08-30 16:24 - (334 Reads)
An unusual delivery service
Is it better to produce locally or to import? That can be a crucial question for simple lifeforms as well. Mitochondria, the power plants of the cell, have their own protein factories although the cell apparatus could easily do the job for them. A special species of eukaryotes even has all the transfer-RNA it needs for protein assembly promptly delivered. Researchers from the University of Bern have now uncovered how this highly unusual import mechanism works in detail.
Link to Press Release(external link)
Ein ungewöhnlicher Lieferservice
Lokal produzieren oder importieren? Das ist auch für simple Lebensformen keine ganz einfache Entscheidung. Die Kraftwerke der Zellen, die sogenannten Mitochondrien, betreiben eigene kleine Proteinfabriken, obwohl sie eigentlich alle Proteine von der Zelle geliefert bekommen könnten. Eine besondere Spezies von Einzellern lässt sich für die Produktion sogar die Transfer-RNA liefern. Berner Forschende haben nun im Detail untersucht, wie dieser ungewöhnliche Molekülimport vonstatten geht.
Link zur Medienmitteilung(external link)
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NCCR Newsletter No. 6

Author: System Administrator - Published At: 2017-07-11 15:39 - (394 Reads)
The Messenger - The NCCR RNA & Disease Newsletter
The sixth edition of the NCCR RNA & Disease Newsletter -The Messenger has been published:
Message from the director’s desk
Oliver Mühlemann
Interview with Thomas R. Cech
"For them, it was a weird organism doing a weird thing"
Research highlights
Protein polymerization preventing pathological aggregation / CLIR sight on protein–RNA interactions
Stefanie Jonas
New NCCR RNA & Disease Junior PI
Announcements
People, events, support grants and more
Read The Messenger here
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FMI News Article

Author: System Administrator - Published At: 2017-07-11 12:00 - (549 Reads)
Preserving the active chromatin state

If cellular identity is to be maintained, it is important that actively transcribed chromatin stretches remain in a loose configuration as long as these genes are needed. Marc Bühler and his group have uncovered a novel positive feedback loop – crucially involving the histone acetyltransferase Mst2 – which ensures that (transcriptionally active) euchromatin cannot be easily converted into (inactive) heterochromatin. Because some of the players in this feedback loop have been implicated in cancer, these findings are relevant to our understanding of human diseases.

Click here to read the whole FMI News Article(external link)
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KTT Flyer of the NCCR RNA & Disease

Author: System Administrator - Published At: 2017-07-11 10:00 - (526 Reads)

Do you need a partner in innovative RNA research?

Have a look at the Knowledge & Technology Transfer (KTT) flyer to learn more about:
Who we are...

What we aim to...

What we focus on...

What we offer...

Click here to download the flyer(external link)

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Welcome to Lukas Jeker!

Author: System Administrator - Published At: 2017-07-04 23:47 - (717 Reads)
We would like to welcome Prof. Lukas Jeker as a new associate member of the NCCR RNA & Disease.
Lukas Jeker is a SNSF assistant professor at the Department of Biomedicine at the University of Basel. The Jeker lab studies the role of microRNAs in the regulation of the immune system.

Website Jeker Lab - University of Basel (external link)
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Jonathan Hall - Portrait of a scientist

Author: System Administrator - Published At: 2017-07-04 13:00 - (949 Reads)
An interview and portrait of Jonathan Hall (Full professor for Pharmaceutical Chemistry at ETH Zurich, NCCR RNA & Disease principal investigator & delegate for Knowledge and Technology Transer) was published in the last edition of the newsletter of the NCCR Chemical Biology.

Link to the portrait of a scientist article in the newsletter of the NCCR Chemical Biology(external link)

Website Hall lab - ETH Zurich(external link)

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FMI News Article

Author: System Administrator - Published At: 2017-06-06 17:33 - (551 Reads)
RNA lifespan determination during transcription

Control of RNA lifespan is vital for the proper functioning of our cells. Marc Bühler's group at the Friedrich Miescher Institute for Biomedical Research (FMI) has discovered a novel mechanism determining the fate of RNA in mammalian cells: two proteins involved in RNA interference - Dgcr8 and Drosha - together with a methyltransferase, Mettl3, mark nascent RNAs for degradation as they are transcribed. This mechanism allows RNA transcripts to "remember" the conditions under which they were synthesized.

Link to FMI News Article(external link)
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Investigation of the role of water molecules in protein RNA-recognition

Author: System Administrator - Published At: 2017-05-24 11:52 - (582 Reads)
The Allain lab (ETH Zurich)(external link) together with the Sponer group (Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic)(external link) has published a paper describing the role of water molecules in the RNA recognition by the RNA recognition motif (RRM) of the Fox-1 protein, which is a regulator of alternative splicing. Its RRM binds to a hexanucleotide RNA target sequence with high affinity and the structure of this complex was determined previously by the Allain lab using Nuclear Magnetic Resonance Spectroscopy (NMR) (Auweter S.D. et. al., (2006) EMBO Journal)(external link). This structure together with a high-resolution X-ray structure of the unbound RRM revealing bound water molecules provided the starting point for molecular dynamics (MD) simulations to further structurally study the role of water in RNA RRM recognition. Based on the results of the MD analyses two selected water binding sites were subsequently studied by NMR, affinity measurements and free-energy calculations. For one of the sites, which is evolutionarily conserved in RRMs, a quantitative agreement between the computational and experimental approaches was found demonstrating the value of MD analyses to analyze hydration patterns involved in RNA-protein recognition.
Read the publications in Nucleic Acids Research (open access)(external link)
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Welcome to Jeffrey Chao and Marc-David Ruepp!

Author: System Administrator - Published At: 2017-05-16 13:41 - (620 Reads)
We would like to welcome Jeffrey Chao (left picture) and Marc-David Ruepp (right picture) who became junior principal investigators of the NCCR RNA & Disease as of May 2017.

Website Chao lab - FMI Basel(external link)

Website Ruepp lab - University of Bern(external link)

Read more about the junior principal investigators of the NCCR RNA & Disease in Vol 5 of the Messenger(external link)

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Press Release / Medienmitteilung Universität Bern

Author: System Administrator - Published At: 2017-05-10 14:07 - (602 Reads)
A possible way to new antibiotics
Two research teams from the University of Bern and the ETH Zurich have developed a new method to shed light onto a mostly unknown process of bacterial protein production. Their results could be used for the design of new antibiotics.
Link to Press Release(external link)

Möglicher Ansatz für neue Antibiotika entdeckt
Zwei Forschungsteams aus Bern und Zürich haben eine neue Methode entwickelt, um einen Einblick in einen bislang kaum erforschten Teil der bakteriellen Proteinherstellung zu erhalten. Die Resultate könnten bei der Entwicklung neuer Antibiotika helfen.
Link zur Medienmitteilung(external link)

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The National Centers of Competence in Research (NCCR) are a research instrument of the Swiss National Science Foundation

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